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Early steps of active DNA demethylation initiated by ROS1 glycosylase require three putative helix-invading residues

Active DNA demethylation is crucial for epigenetic control, but the underlying enzymatic mechanisms are incompletely understood. REPRESSOR OF SILENCING 1 (ROS1) is a 5-methylcytosine (5-meC) DNA glycosylase/lyase that initiates DNA demethylation in plants through a base excision repair process. The...

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Detalles Bibliográficos
Autores principales:	Parrilla-Doblas, Jara Teresa, Ponferrada-Marín, María Isabel, Roldán-Arjona, Teresa, Ariza, Rafael R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794587/ https://www.ncbi.nlm.nih.gov/pubmed/23868090 http://dx.doi.org/10.1093/nar/gkt625

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