BRCA1 is a key regulator of breast differentiation through activation of Notch signalling with implications for anti-endocrine treatment of breast cancers

Here, we show for the first time, that the familial breast/ovarian cancer susceptibility gene BRCA1 activates the Notch pathway in breast cells by transcriptional upregulation of Notch ligands and receptors in both normal and cancer cells. We demonstrate through chromatin immunoprecipitation assays...

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Detalles Bibliográficos
Autores principales: Buckley, Niamh E., Nic An tSaoir, Caoimhe B., Blayney, Jaine K., Oram, Lisa C., Crawford, Nyree T., D’Costa, Zenobia C., Quinn, Jennifer E., Kennedy, Richard D., Harkin, D. Paul, Mullan, Paul B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794588/
https://www.ncbi.nlm.nih.gov/pubmed/23863842
http://dx.doi.org/10.1093/nar/gkt626

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794588/
https://www.ncbi.nlm.nih.gov/pubmed/23863842
http://dx.doi.org/10.1093/nar/gkt626

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