SIRT6 exhibits nucleosome-dependent deacetylase activity

The SIRT6 deacetylase is a key regulator of mammalian genome stability, metabolism and lifespan. Previous studies indicated that SIRT6 exhibits poor deacetylase activity in vitro. Here, we explored the specific conditions that allow SIRT6 to function as a significant deacetylase. We show that SIRT6...

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Detalles Bibliográficos
Autores principales: Gil, Reuven, Barth, Shaul, Kanfi, Yariv, Cohen, Haim Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794599/
https://www.ncbi.nlm.nih.gov/pubmed/23892288
http://dx.doi.org/10.1093/nar/gkt642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794599/
https://www.ncbi.nlm.nih.gov/pubmed/23892288
http://dx.doi.org/10.1093/nar/gkt642

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