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The Pyridoxal 5′-Phosphate (PLP)-Dependent Enzyme Serine Palmitoyltransferase (SPT): Effects of the Small Subunits and Insights from Bacterial Mimics of Human hLCB2a HSAN1 Mutations

The pyridoxal 5′-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT) catalyses the first step of de novo sphingolipid biosynthesis. The core human enzyme is a membrane-bound heterodimer composed of two subunits (hLCB1 and hLCB2a/b), and mutations in both hLCB1 (e.g., C133W and C133Y)...

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Detalles Bibliográficos
Autores principales:	Beattie, Ashley E., Gupta, Sita D., Frankova, Lenka, Kazlauskaite, Agne, Harmon, Jeffrey M., Dunn, Teresa M., Campopiano, Dominic J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794620/ https://www.ncbi.nlm.nih.gov/pubmed/24175284 http://dx.doi.org/10.1155/2013/194371

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