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Helical Irradiation of the Total Skin with Dose Painting to Replace Total Skin Electron Beam Therapy for Therapy-Refractory Cutaneous CD4+ T-Cell Lymphoma

A 36-year-old woman was diagnosed with a therapy-refractory cutaneous CD4+ T-cell lymphoma, T3N0M0B0, and stage IIB. Helical irradiation of the total skin (HITS) and dose painting techniques, with 30 Gy in 40 fractions interrupted at 20 fractions with one week resting, 4 times per week were prescrib...

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Autores principales: Hsieh, Chen-Hsi, Shueng, Pei-Wei, Lin, Shih-Chiang, Tien, Hui-Ju, Shiau, An-Cheng, Chou, Yueh-Hung, Wu, Meng-Hao, Wang, Jen-Yu, Chen, Chi-Kuan, Chen, Yu-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794623/
https://www.ncbi.nlm.nih.gov/pubmed/24175298
http://dx.doi.org/10.1155/2013/717589
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author Hsieh, Chen-Hsi
Shueng, Pei-Wei
Lin, Shih-Chiang
Tien, Hui-Ju
Shiau, An-Cheng
Chou, Yueh-Hung
Wu, Meng-Hao
Wang, Jen-Yu
Chen, Chi-Kuan
Chen, Yu-Jen
author_facet Hsieh, Chen-Hsi
Shueng, Pei-Wei
Lin, Shih-Chiang
Tien, Hui-Ju
Shiau, An-Cheng
Chou, Yueh-Hung
Wu, Meng-Hao
Wang, Jen-Yu
Chen, Chi-Kuan
Chen, Yu-Jen
author_sort Hsieh, Chen-Hsi
collection PubMed
description A 36-year-old woman was diagnosed with a therapy-refractory cutaneous CD4+ T-cell lymphoma, T3N0M0B0, and stage IIB. Helical irradiation of the total skin (HITS) and dose painting techniques, with 30 Gy in 40 fractions interrupted at 20 fractions with one week resting, 4 times per week were prescribed. The diving suit was dressed whole body to increase the superficial dose and using central core complete block (CCCB) technique for reducing the internal organ dose. The mean doses of critical organs of head, chest, and abdomen were 2.1 to 29.9 Gy, 2.9 to 8.1 Gy, and 3.6 to 15.7 Gy, respectively. The mean dose of lesions was 84.0 cGy. The dosage of left side pretreated area was decreased 57%. The tumor regressed progressively without further noduloplaques. During the HITS procedure, most toxicity was grade I except leukocytopenia with grade 3. No epitheliolysis, phlyctenules, tumor lysis syndrome, fever, vomiting, dyspnea, edema of the extremities, or diarrhea occurred during the treatment. HITS with dose painting techniques provides precise dosage delivery with impressive results, sparing critical organs, and offering limited transient and chronic sequelae for previously locally irradiated, therapy-refractory cutaneous T-cell lymphoma.
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spelling pubmed-37946232013-10-30 Helical Irradiation of the Total Skin with Dose Painting to Replace Total Skin Electron Beam Therapy for Therapy-Refractory Cutaneous CD4+ T-Cell Lymphoma Hsieh, Chen-Hsi Shueng, Pei-Wei Lin, Shih-Chiang Tien, Hui-Ju Shiau, An-Cheng Chou, Yueh-Hung Wu, Meng-Hao Wang, Jen-Yu Chen, Chi-Kuan Chen, Yu-Jen Biomed Res Int Research Article A 36-year-old woman was diagnosed with a therapy-refractory cutaneous CD4+ T-cell lymphoma, T3N0M0B0, and stage IIB. Helical irradiation of the total skin (HITS) and dose painting techniques, with 30 Gy in 40 fractions interrupted at 20 fractions with one week resting, 4 times per week were prescribed. The diving suit was dressed whole body to increase the superficial dose and using central core complete block (CCCB) technique for reducing the internal organ dose. The mean doses of critical organs of head, chest, and abdomen were 2.1 to 29.9 Gy, 2.9 to 8.1 Gy, and 3.6 to 15.7 Gy, respectively. The mean dose of lesions was 84.0 cGy. The dosage of left side pretreated area was decreased 57%. The tumor regressed progressively without further noduloplaques. During the HITS procedure, most toxicity was grade I except leukocytopenia with grade 3. No epitheliolysis, phlyctenules, tumor lysis syndrome, fever, vomiting, dyspnea, edema of the extremities, or diarrhea occurred during the treatment. HITS with dose painting techniques provides precise dosage delivery with impressive results, sparing critical organs, and offering limited transient and chronic sequelae for previously locally irradiated, therapy-refractory cutaneous T-cell lymphoma. Hindawi Publishing Corporation 2013 2013-09-23 /pmc/articles/PMC3794623/ /pubmed/24175298 http://dx.doi.org/10.1155/2013/717589 Text en Copyright © 2013 Chen-Hsi Hsieh et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hsieh, Chen-Hsi
Shueng, Pei-Wei
Lin, Shih-Chiang
Tien, Hui-Ju
Shiau, An-Cheng
Chou, Yueh-Hung
Wu, Meng-Hao
Wang, Jen-Yu
Chen, Chi-Kuan
Chen, Yu-Jen
Helical Irradiation of the Total Skin with Dose Painting to Replace Total Skin Electron Beam Therapy for Therapy-Refractory Cutaneous CD4+ T-Cell Lymphoma
title Helical Irradiation of the Total Skin with Dose Painting to Replace Total Skin Electron Beam Therapy for Therapy-Refractory Cutaneous CD4+ T-Cell Lymphoma
title_full Helical Irradiation of the Total Skin with Dose Painting to Replace Total Skin Electron Beam Therapy for Therapy-Refractory Cutaneous CD4+ T-Cell Lymphoma
title_fullStr Helical Irradiation of the Total Skin with Dose Painting to Replace Total Skin Electron Beam Therapy for Therapy-Refractory Cutaneous CD4+ T-Cell Lymphoma
title_full_unstemmed Helical Irradiation of the Total Skin with Dose Painting to Replace Total Skin Electron Beam Therapy for Therapy-Refractory Cutaneous CD4+ T-Cell Lymphoma
title_short Helical Irradiation of the Total Skin with Dose Painting to Replace Total Skin Electron Beam Therapy for Therapy-Refractory Cutaneous CD4+ T-Cell Lymphoma
title_sort helical irradiation of the total skin with dose painting to replace total skin electron beam therapy for therapy-refractory cutaneous cd4+ t-cell lymphoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794623/
https://www.ncbi.nlm.nih.gov/pubmed/24175298
http://dx.doi.org/10.1155/2013/717589
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