The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats

The aim of this study was to investigate the protective effect of cordymin on diabetic osteopenia in alloxan-induced diabetic rats and the possible mechanisms involved. The diabetic rats received daily intraperitoneal injection with cordymin (20, 50, and 100 mg/kg/day) for 5 weeks. Cordymin could re...

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Autores principales: Qi, Wei, Zhang, Yang, Yan, Ya-bo, Lei, Wei, Wu, Zi-xiang, Liu, Ning, Liu, Shuai, Shi, Lei, Fan, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794654/
https://www.ncbi.nlm.nih.gov/pubmed/24174985
http://dx.doi.org/10.1155/2013/985636
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author Qi, Wei
Zhang, Yang
Yan, Ya-bo
Lei, Wei
Wu, Zi-xiang
Liu, Ning
Liu, Shuai
Shi, Lei
Fan, Yong
author_facet Qi, Wei
Zhang, Yang
Yan, Ya-bo
Lei, Wei
Wu, Zi-xiang
Liu, Ning
Liu, Shuai
Shi, Lei
Fan, Yong
author_sort Qi, Wei
collection PubMed
description The aim of this study was to investigate the protective effect of cordymin on diabetic osteopenia in alloxan-induced diabetic rats and the possible mechanisms involved. The diabetic rats received daily intraperitoneal injection with cordymin (20, 50, and 100 mg/kg/day) for 5 weeks. Cordymin could restore the circulating blood glucose, glycosylated hemoglobin (HbA1c), serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), and insulin levels in a dose-dependent manner. Also, the treatment of diabetic rats with cordymin could partially reverse the β cells death and decrease the total antioxidant status (TAOS) in the diabetic rats. The results may directly and indirectly account for the possible mechanism of the beneficial effect of cordymin on diabetic osteopenia, which was confirmed with the increased bone mineral content (BMC) and bone mineral density (BMD) in diabetic rats (P < 0.05). All those findings indicate that cordymin may play a protective role in diabetic osteoporosis.
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spelling pubmed-37946542013-10-30 The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats Qi, Wei Zhang, Yang Yan, Ya-bo Lei, Wei Wu, Zi-xiang Liu, Ning Liu, Shuai Shi, Lei Fan, Yong Evid Based Complement Alternat Med Research Article The aim of this study was to investigate the protective effect of cordymin on diabetic osteopenia in alloxan-induced diabetic rats and the possible mechanisms involved. The diabetic rats received daily intraperitoneal injection with cordymin (20, 50, and 100 mg/kg/day) for 5 weeks. Cordymin could restore the circulating blood glucose, glycosylated hemoglobin (HbA1c), serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), and insulin levels in a dose-dependent manner. Also, the treatment of diabetic rats with cordymin could partially reverse the β cells death and decrease the total antioxidant status (TAOS) in the diabetic rats. The results may directly and indirectly account for the possible mechanism of the beneficial effect of cordymin on diabetic osteopenia, which was confirmed with the increased bone mineral content (BMC) and bone mineral density (BMD) in diabetic rats (P < 0.05). All those findings indicate that cordymin may play a protective role in diabetic osteoporosis. Hindawi Publishing Corporation 2013 2013-09-22 /pmc/articles/PMC3794654/ /pubmed/24174985 http://dx.doi.org/10.1155/2013/985636 Text en Copyright © 2013 Wei Qi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Qi, Wei
Zhang, Yang
Yan, Ya-bo
Lei, Wei
Wu, Zi-xiang
Liu, Ning
Liu, Shuai
Shi, Lei
Fan, Yong
The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats
title The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats
title_full The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats
title_fullStr The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats
title_full_unstemmed The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats
title_short The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats
title_sort protective effect of cordymin, a peptide purified from the medicinal mushroom cordyceps sinensis, on diabetic osteopenia in alloxan-induced diabetic rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794654/
https://www.ncbi.nlm.nih.gov/pubmed/24174985
http://dx.doi.org/10.1155/2013/985636
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