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Potential Targets for Colorectal Cancer Prevention

The step-wise development of colorectal neoplasia from adenoma to carcinoma suggests that specific interventions could delay or prevent the development of invasive cancer. Several key factors involved in colorectal cancer pathogenesis have already been identified including cyclooxygenase 2 (COX-2),...

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Detalles Bibliográficos
Autores principales: Temraz, Sally, Mukherji, Deborah, Shamseddine, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794728/
https://www.ncbi.nlm.nih.gov/pubmed/23975167
http://dx.doi.org/10.3390/ijms140917279
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author Temraz, Sally
Mukherji, Deborah
Shamseddine, Ali
author_facet Temraz, Sally
Mukherji, Deborah
Shamseddine, Ali
author_sort Temraz, Sally
collection PubMed
description The step-wise development of colorectal neoplasia from adenoma to carcinoma suggests that specific interventions could delay or prevent the development of invasive cancer. Several key factors involved in colorectal cancer pathogenesis have already been identified including cyclooxygenase 2 (COX-2), nuclear factor kappa B (NF-κB), survivin and insulin-like growth factor-I (IGF-I). Clinical trials of COX-2 inhibitors have provided the “proof of principle” that inhibition of this enzyme can prevent the formation of colonic adenomas and potentially carcinomas, however concerns regarding the potential toxicity of these drugs have limited their use as a chemopreventative strategy. Curcumin, resveratrol and quercetin are chemopreventive agents that are able to suppress multiple signaling pathways involved in carcinogenesis and hence are attractive candidates for further research.
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spelling pubmed-37947282013-10-21 Potential Targets for Colorectal Cancer Prevention Temraz, Sally Mukherji, Deborah Shamseddine, Ali Int J Mol Sci Review The step-wise development of colorectal neoplasia from adenoma to carcinoma suggests that specific interventions could delay or prevent the development of invasive cancer. Several key factors involved in colorectal cancer pathogenesis have already been identified including cyclooxygenase 2 (COX-2), nuclear factor kappa B (NF-κB), survivin and insulin-like growth factor-I (IGF-I). Clinical trials of COX-2 inhibitors have provided the “proof of principle” that inhibition of this enzyme can prevent the formation of colonic adenomas and potentially carcinomas, however concerns regarding the potential toxicity of these drugs have limited their use as a chemopreventative strategy. Curcumin, resveratrol and quercetin are chemopreventive agents that are able to suppress multiple signaling pathways involved in carcinogenesis and hence are attractive candidates for further research. MDPI 2013-08-22 /pmc/articles/PMC3794728/ /pubmed/23975167 http://dx.doi.org/10.3390/ijms140917279 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Temraz, Sally
Mukherji, Deborah
Shamseddine, Ali
Potential Targets for Colorectal Cancer Prevention
title Potential Targets for Colorectal Cancer Prevention
title_full Potential Targets for Colorectal Cancer Prevention
title_fullStr Potential Targets for Colorectal Cancer Prevention
title_full_unstemmed Potential Targets for Colorectal Cancer Prevention
title_short Potential Targets for Colorectal Cancer Prevention
title_sort potential targets for colorectal cancer prevention
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794728/
https://www.ncbi.nlm.nih.gov/pubmed/23975167
http://dx.doi.org/10.3390/ijms140917279
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