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Potential Targets for Colorectal Cancer Prevention
The step-wise development of colorectal neoplasia from adenoma to carcinoma suggests that specific interventions could delay or prevent the development of invasive cancer. Several key factors involved in colorectal cancer pathogenesis have already been identified including cyclooxygenase 2 (COX-2),...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794728/ https://www.ncbi.nlm.nih.gov/pubmed/23975167 http://dx.doi.org/10.3390/ijms140917279 |
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author | Temraz, Sally Mukherji, Deborah Shamseddine, Ali |
author_facet | Temraz, Sally Mukherji, Deborah Shamseddine, Ali |
author_sort | Temraz, Sally |
collection | PubMed |
description | The step-wise development of colorectal neoplasia from adenoma to carcinoma suggests that specific interventions could delay or prevent the development of invasive cancer. Several key factors involved in colorectal cancer pathogenesis have already been identified including cyclooxygenase 2 (COX-2), nuclear factor kappa B (NF-κB), survivin and insulin-like growth factor-I (IGF-I). Clinical trials of COX-2 inhibitors have provided the “proof of principle” that inhibition of this enzyme can prevent the formation of colonic adenomas and potentially carcinomas, however concerns regarding the potential toxicity of these drugs have limited their use as a chemopreventative strategy. Curcumin, resveratrol and quercetin are chemopreventive agents that are able to suppress multiple signaling pathways involved in carcinogenesis and hence are attractive candidates for further research. |
format | Online Article Text |
id | pubmed-3794728 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-37947282013-10-21 Potential Targets for Colorectal Cancer Prevention Temraz, Sally Mukherji, Deborah Shamseddine, Ali Int J Mol Sci Review The step-wise development of colorectal neoplasia from adenoma to carcinoma suggests that specific interventions could delay or prevent the development of invasive cancer. Several key factors involved in colorectal cancer pathogenesis have already been identified including cyclooxygenase 2 (COX-2), nuclear factor kappa B (NF-κB), survivin and insulin-like growth factor-I (IGF-I). Clinical trials of COX-2 inhibitors have provided the “proof of principle” that inhibition of this enzyme can prevent the formation of colonic adenomas and potentially carcinomas, however concerns regarding the potential toxicity of these drugs have limited their use as a chemopreventative strategy. Curcumin, resveratrol and quercetin are chemopreventive agents that are able to suppress multiple signaling pathways involved in carcinogenesis and hence are attractive candidates for further research. MDPI 2013-08-22 /pmc/articles/PMC3794728/ /pubmed/23975167 http://dx.doi.org/10.3390/ijms140917279 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Temraz, Sally Mukherji, Deborah Shamseddine, Ali Potential Targets for Colorectal Cancer Prevention |
title | Potential Targets for Colorectal Cancer Prevention |
title_full | Potential Targets for Colorectal Cancer Prevention |
title_fullStr | Potential Targets for Colorectal Cancer Prevention |
title_full_unstemmed | Potential Targets for Colorectal Cancer Prevention |
title_short | Potential Targets for Colorectal Cancer Prevention |
title_sort | potential targets for colorectal cancer prevention |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794728/ https://www.ncbi.nlm.nih.gov/pubmed/23975167 http://dx.doi.org/10.3390/ijms140917279 |
work_keys_str_mv | AT temrazsally potentialtargetsforcolorectalcancerprevention AT mukherjideborah potentialtargetsforcolorectalcancerprevention AT shamseddineali potentialtargetsforcolorectalcancerprevention |