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PCA3 and PCA3-Based Nomograms Improve Diagnostic Accuracy in Patients Undergoing First Prostate Biopsy

While now recognized as an aid to predict repeat prostate biopsy outcome, the urinary PCA3 (prostate cancer gene 3) test has also been recently advocated to predict initial biopsy results. The objective is to evaluate the performance of the PCA3 test in predicting results of initial prostate biopsie...

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Autores principales: Ruffion, Alain, Devonec, Marian, Champetier, Denis, Decaussin-Petrucci, Myriam, Rodriguez-Lafrasse, Claire, Paparel, Philippe, Perrin, Paul, Vlaeminck-Guillem, Virginie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794752/
https://www.ncbi.nlm.nih.gov/pubmed/23994838
http://dx.doi.org/10.3390/ijms140917767
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author Ruffion, Alain
Devonec, Marian
Champetier, Denis
Decaussin-Petrucci, Myriam
Rodriguez-Lafrasse, Claire
Paparel, Philippe
Perrin, Paul
Vlaeminck-Guillem, Virginie
author_facet Ruffion, Alain
Devonec, Marian
Champetier, Denis
Decaussin-Petrucci, Myriam
Rodriguez-Lafrasse, Claire
Paparel, Philippe
Perrin, Paul
Vlaeminck-Guillem, Virginie
author_sort Ruffion, Alain
collection PubMed
description While now recognized as an aid to predict repeat prostate biopsy outcome, the urinary PCA3 (prostate cancer gene 3) test has also been recently advocated to predict initial biopsy results. The objective is to evaluate the performance of the PCA3 test in predicting results of initial prostate biopsies and to determine whether its incorporation into specific nomograms reinforces its diagnostic value. A prospective study included 601 consecutive patients addressed for initial prostate biopsy. The PCA3 test was performed before ≥12-core initial prostate biopsy, along with standard risk factor assessment. Diagnostic performance of the PCA3 test was evaluated. The three available nomograms (Hansen’s and Chun’s nomograms, as well as the updated Prostate Cancer Prevention Trial risk calculator; PCPT) were applied to the cohort, and their predictive accuracies were assessed in terms of biopsy outcome: the presence of any prostate cancer (PCa) and high-grade prostate cancer (HGPCa). The PCA3 score provided significant predictive accuracy. While the PCPT risk calculator appeared less accurate; both Chun’s and Hansen’s nomograms provided good calibration and high net benefit on decision curve analyses. When applying nomogram-derived PCa probability thresholds ≤30%, ≤6% of HGPCa would have been missed, while avoiding up to 48% of unnecessary biopsies. The urinary PCA3 test and PCA3-incorporating nomograms can be considered as reliable tools to aid in the initial biopsy decision.
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spelling pubmed-37947522013-10-21 PCA3 and PCA3-Based Nomograms Improve Diagnostic Accuracy in Patients Undergoing First Prostate Biopsy Ruffion, Alain Devonec, Marian Champetier, Denis Decaussin-Petrucci, Myriam Rodriguez-Lafrasse, Claire Paparel, Philippe Perrin, Paul Vlaeminck-Guillem, Virginie Int J Mol Sci Article While now recognized as an aid to predict repeat prostate biopsy outcome, the urinary PCA3 (prostate cancer gene 3) test has also been recently advocated to predict initial biopsy results. The objective is to evaluate the performance of the PCA3 test in predicting results of initial prostate biopsies and to determine whether its incorporation into specific nomograms reinforces its diagnostic value. A prospective study included 601 consecutive patients addressed for initial prostate biopsy. The PCA3 test was performed before ≥12-core initial prostate biopsy, along with standard risk factor assessment. Diagnostic performance of the PCA3 test was evaluated. The three available nomograms (Hansen’s and Chun’s nomograms, as well as the updated Prostate Cancer Prevention Trial risk calculator; PCPT) were applied to the cohort, and their predictive accuracies were assessed in terms of biopsy outcome: the presence of any prostate cancer (PCa) and high-grade prostate cancer (HGPCa). The PCA3 score provided significant predictive accuracy. While the PCPT risk calculator appeared less accurate; both Chun’s and Hansen’s nomograms provided good calibration and high net benefit on decision curve analyses. When applying nomogram-derived PCa probability thresholds ≤30%, ≤6% of HGPCa would have been missed, while avoiding up to 48% of unnecessary biopsies. The urinary PCA3 test and PCA3-incorporating nomograms can be considered as reliable tools to aid in the initial biopsy decision. MDPI 2013-08-29 /pmc/articles/PMC3794752/ /pubmed/23994838 http://dx.doi.org/10.3390/ijms140917767 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Ruffion, Alain
Devonec, Marian
Champetier, Denis
Decaussin-Petrucci, Myriam
Rodriguez-Lafrasse, Claire
Paparel, Philippe
Perrin, Paul
Vlaeminck-Guillem, Virginie
PCA3 and PCA3-Based Nomograms Improve Diagnostic Accuracy in Patients Undergoing First Prostate Biopsy
title PCA3 and PCA3-Based Nomograms Improve Diagnostic Accuracy in Patients Undergoing First Prostate Biopsy
title_full PCA3 and PCA3-Based Nomograms Improve Diagnostic Accuracy in Patients Undergoing First Prostate Biopsy
title_fullStr PCA3 and PCA3-Based Nomograms Improve Diagnostic Accuracy in Patients Undergoing First Prostate Biopsy
title_full_unstemmed PCA3 and PCA3-Based Nomograms Improve Diagnostic Accuracy in Patients Undergoing First Prostate Biopsy
title_short PCA3 and PCA3-Based Nomograms Improve Diagnostic Accuracy in Patients Undergoing First Prostate Biopsy
title_sort pca3 and pca3-based nomograms improve diagnostic accuracy in patients undergoing first prostate biopsy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794752/
https://www.ncbi.nlm.nih.gov/pubmed/23994838
http://dx.doi.org/10.3390/ijms140917767
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