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hnRNP A1: The Swiss Army Knife of Gene Expression
Eukaryotic cells express a large variety of RNA binding proteins (RBPs), with diverse affinities and specificities towards target RNAs. These proteins play a crucial role in almost every aspect of RNA biogenesis, expression and function. The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a co...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794818/ https://www.ncbi.nlm.nih.gov/pubmed/24065100 http://dx.doi.org/10.3390/ijms140918999 |
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author | Jean-Philippe, Jacques Paz, Sean Caputi, Massimo |
author_facet | Jean-Philippe, Jacques Paz, Sean Caputi, Massimo |
author_sort | Jean-Philippe, Jacques |
collection | PubMed |
description | Eukaryotic cells express a large variety of RNA binding proteins (RBPs), with diverse affinities and specificities towards target RNAs. These proteins play a crucial role in almost every aspect of RNA biogenesis, expression and function. The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a complex and diverse family of RNA binding proteins. hnRNPs display multiple functions in the processing of heterogeneous nuclear RNAs into mature messenger RNAs. hnRNP A1 is one of the most abundant and ubiquitously expressed members of this protein family. hnRNP A1 plays multiple roles in gene expression by regulating major steps in the processing of nascent RNA transcripts. The transcription, splicing, stability, export through nuclear pores and translation of cellular and viral transcripts are all mechanisms modulated by this protein. The diverse functions played by hnRNP A1 are not limited to mRNA biogenesis, but extend to the processing of microRNAs, telomere maintenance and the regulation of transcription factor activity. Genomic approaches have recently uncovered the extent of hnRNP A1 roles in the development and differentiation of living organisms. The aim of this review is to highlight recent developments in the study of this protein and to describe its functions in cellular and viral gene expression and its role in human pathologies. |
format | Online Article Text |
id | pubmed-3794818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-37948182013-10-21 hnRNP A1: The Swiss Army Knife of Gene Expression Jean-Philippe, Jacques Paz, Sean Caputi, Massimo Int J Mol Sci Review Eukaryotic cells express a large variety of RNA binding proteins (RBPs), with diverse affinities and specificities towards target RNAs. These proteins play a crucial role in almost every aspect of RNA biogenesis, expression and function. The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a complex and diverse family of RNA binding proteins. hnRNPs display multiple functions in the processing of heterogeneous nuclear RNAs into mature messenger RNAs. hnRNP A1 is one of the most abundant and ubiquitously expressed members of this protein family. hnRNP A1 plays multiple roles in gene expression by regulating major steps in the processing of nascent RNA transcripts. The transcription, splicing, stability, export through nuclear pores and translation of cellular and viral transcripts are all mechanisms modulated by this protein. The diverse functions played by hnRNP A1 are not limited to mRNA biogenesis, but extend to the processing of microRNAs, telomere maintenance and the regulation of transcription factor activity. Genomic approaches have recently uncovered the extent of hnRNP A1 roles in the development and differentiation of living organisms. The aim of this review is to highlight recent developments in the study of this protein and to describe its functions in cellular and viral gene expression and its role in human pathologies. MDPI 2013-09-16 /pmc/articles/PMC3794818/ /pubmed/24065100 http://dx.doi.org/10.3390/ijms140918999 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Jean-Philippe, Jacques Paz, Sean Caputi, Massimo hnRNP A1: The Swiss Army Knife of Gene Expression |
title | hnRNP A1: The Swiss Army Knife of Gene Expression |
title_full | hnRNP A1: The Swiss Army Knife of Gene Expression |
title_fullStr | hnRNP A1: The Swiss Army Knife of Gene Expression |
title_full_unstemmed | hnRNP A1: The Swiss Army Knife of Gene Expression |
title_short | hnRNP A1: The Swiss Army Knife of Gene Expression |
title_sort | hnrnp a1: the swiss army knife of gene expression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794818/ https://www.ncbi.nlm.nih.gov/pubmed/24065100 http://dx.doi.org/10.3390/ijms140918999 |
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