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Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol

The predominant mechanism of drug resistance in African trypanosomes is decreased drug uptake due to loss-of-function mutations in the genes for the transporters that mediate drug import. The role of transporters as determinants of drug susceptibility is well documented from laboratory-selected Tryp...

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Detalles Bibliográficos
Autores principales:	Graf, Fabrice E., Ludin, Philipp, Wenzler, Tanja, Kaiser, Marcel, Brun, Reto, Pyana, Patient Pati, Büscher, Philippe, de Koning, Harry P., Horn, David, Mäser, Pascal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794916/ https://www.ncbi.nlm.nih.gov/pubmed/24130910 http://dx.doi.org/10.1371/journal.pntd.0002475

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