Quaternary Structure of Pathological Prion Protein as a Determining Factor of Strain-Specific Prion Replication Dynamics

Prions are proteinaceous infectious agents responsible for fatal neurodegenerative diseases in animals and humans. They are essentially composed of PrP(Sc), an aggregated, misfolded conformer of the ubiquitously expressed host-encoded prion protein (PrP(C)). Stable variations in PrP(Sc) conformation...

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Detalles Bibliográficos
Autores principales: Laferrière, Florent, Tixador, Philippe, Moudjou, Mohammed, Chapuis, Jérôme, Sibille, Pierre, Herzog, Laetitia, Reine, Fabienne, Jaumain, Emilie, Laude, Hubert, Rezaei, Human, Béringue, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795044/
https://www.ncbi.nlm.nih.gov/pubmed/24130496
http://dx.doi.org/10.1371/journal.ppat.1003702

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