O-mannosylation of the Mycobacterium tuberculosis Adhesin Apa Is Crucial for T Cell Antigenicity during Infection but Is Expendable for Protection

Glycosylation is the most abundant post-translational polypeptide chain modification in nature. Although carbohydrate modification of protein antigens from many microbial pathogens constitutes important components of B cell epitopes, the role in T cell immunity is not completely understood. Here, us...

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Detalles Bibliográficos
Autores principales: Nandakumar, Subhadra, Kannanganat, Sunil, Dobos, Karen M., Lucas, Megan, Spencer, John S., Fang, Sunan, McDonald, Melissa A., Pohl, Jan, Birkness, Kristin, Chamcha, Venkateswarlu, Ramirez, Melissa V., Plikaytis, Bonnie B., Posey, James E., Amara, Rama Rao, Sable, Suraj B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795050/
https://www.ncbi.nlm.nih.gov/pubmed/24130497
http://dx.doi.org/10.1371/journal.ppat.1003705

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