Cargando…
Combination of Rapamycin, CI-1040, and 17-AAG Inhibits Metastatic Capacity of Prostate Cancer via Slug Inhibition
Though prostate cancer (PCa) has slow progression, the hormone refractory (HRCP) and metastatic entities are substantially lethal and lack effective treatments. Transcription factor Slug is critical in regulating metastases of various tumors including PCa. Here we studied targeted therapy against Sl...
Autores principales: | Ding, Guanxiong, Feng, Chenchen, Jiang, Haowen, Ding, Qiang, Zhang, Limin, Na, Rong, Xu, Hua, Liu, Jun |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795052/ https://www.ncbi.nlm.nih.gov/pubmed/24130883 http://dx.doi.org/10.1371/journal.pone.0077400 |
Ejemplares similares
-
Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound
por: Bruchhagen, Christin, et al.
Publicado: (2018) -
Inhibiting ERK Activation with CI-1040 Leads to Compensatory Upregulation of Alternate MAPKs and Plasminogen Activator Inhibitor-1 following Subtotal Nephrectomy with No Impact on Kidney Fibrosis
por: Nutter, Faith Hannah, et al.
Publicado: (2015) -
The antitumor natural product tanshinone IIA inhibits protein kinase C and acts synergistically with 17-AAG
por: Lv, Chao, et al.
Publicado: (2018) -
Modeling tandem AAG8-MEK inhibition in melanoma cells
por: Sun, Bing, et al.
Publicado: (2014) -
A Novel Mechanism of 17-AAG Therapeutic Efficacy on HSP90 Inhibition in MYCN-Amplified Neuroblastoma Cells
por: Hanna, Reine, et al.
Publicado: (2021)