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RET Fusion Genes in Korean Non-Small Cell Lung Cancer
Recently, rearranged during transfection (RET) fusions have been identified in approximately 1% of non-small cell lung cancer (NSCLC). To know the prevalence of RET fusion genes in Korean NSCLCs, we examined the RET fusion genes in 156 surgically resected NSCLCs using a reverse transcriptase polymer...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795183/ https://www.ncbi.nlm.nih.gov/pubmed/24133367 http://dx.doi.org/10.3346/jkms.2013.28.10.1555 |
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author | Yoo, Seung Soo Jin, Guang Jung, Hye Jin Hong, Mi Jeong Choi, Jin Eun Jeon, Hyo-Sung Lee, Shin Yup Lim, Jeong Ok Park, Jae Yong |
author_facet | Yoo, Seung Soo Jin, Guang Jung, Hye Jin Hong, Mi Jeong Choi, Jin Eun Jeon, Hyo-Sung Lee, Shin Yup Lim, Jeong Ok Park, Jae Yong |
author_sort | Yoo, Seung Soo |
collection | PubMed |
description | Recently, rearranged during transfection (RET) fusions have been identified in approximately 1% of non-small cell lung cancer (NSCLC). To know the prevalence of RET fusion genes in Korean NSCLCs, we examined the RET fusion genes in 156 surgically resected NSCLCs using a reverse transcriptase polymerase chain reaction. Two KIF5B-RET fusions and one CCDC6-RET fusion were identified. All three patients were females and never smokers with adenocarcinomas. RET fusion genes were mutually exclusive from EGFR, KRAS mutations and EML4-ALK fusion. RET fusion genes occur 1.9% (3 of 156) of surgically treated NSCLC patients in Koreans. |
format | Online Article Text |
id | pubmed-3795183 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-37951832013-10-16 RET Fusion Genes in Korean Non-Small Cell Lung Cancer Yoo, Seung Soo Jin, Guang Jung, Hye Jin Hong, Mi Jeong Choi, Jin Eun Jeon, Hyo-Sung Lee, Shin Yup Lim, Jeong Ok Park, Jae Yong J Korean Med Sci Brief Communication Recently, rearranged during transfection (RET) fusions have been identified in approximately 1% of non-small cell lung cancer (NSCLC). To know the prevalence of RET fusion genes in Korean NSCLCs, we examined the RET fusion genes in 156 surgically resected NSCLCs using a reverse transcriptase polymerase chain reaction. Two KIF5B-RET fusions and one CCDC6-RET fusion were identified. All three patients were females and never smokers with adenocarcinomas. RET fusion genes were mutually exclusive from EGFR, KRAS mutations and EML4-ALK fusion. RET fusion genes occur 1.9% (3 of 156) of surgically treated NSCLC patients in Koreans. The Korean Academy of Medical Sciences 2013-10 2013-09-25 /pmc/articles/PMC3795183/ /pubmed/24133367 http://dx.doi.org/10.3346/jkms.2013.28.10.1555 Text en © 2013 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Communication Yoo, Seung Soo Jin, Guang Jung, Hye Jin Hong, Mi Jeong Choi, Jin Eun Jeon, Hyo-Sung Lee, Shin Yup Lim, Jeong Ok Park, Jae Yong RET Fusion Genes in Korean Non-Small Cell Lung Cancer |
title | RET Fusion Genes in Korean Non-Small Cell Lung Cancer |
title_full | RET Fusion Genes in Korean Non-Small Cell Lung Cancer |
title_fullStr | RET Fusion Genes in Korean Non-Small Cell Lung Cancer |
title_full_unstemmed | RET Fusion Genes in Korean Non-Small Cell Lung Cancer |
title_short | RET Fusion Genes in Korean Non-Small Cell Lung Cancer |
title_sort | ret fusion genes in korean non-small cell lung cancer |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795183/ https://www.ncbi.nlm.nih.gov/pubmed/24133367 http://dx.doi.org/10.3346/jkms.2013.28.10.1555 |
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