Dynamic Regulation of Ero1α and Peroxiredoxin 4 Localization in the Secretory Pathway

In the early secretory compartment (ESC), a network of chaperones and enzymes assists oxidative folding of nascent proteins. Ero1 flavoproteins oxidize protein disulfide isomerase (PDI), generating H(2)O(2) as a byproduct. Peroxiredoxin 4 (Prx4) can utilize luminal H(2)O(2) to oxidize PDI, thus favo...

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Detalles Bibliográficos
Autores principales: Kakihana, Taichi, Araki, Kazutaka, Vavassori, Stefano, Iemura, Shun-ichiro, Cortini, Margherita, Fagioli, Claudio, Natsume, Tohru, Sitia, Roberto, Nagata, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795256/
https://www.ncbi.nlm.nih.gov/pubmed/23979138
http://dx.doi.org/10.1074/jbc.M113.467845

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