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Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay

Migratory cells, including mammalian leukocytes and Dictyostelium, use G-protein-coupled receptor (GPCR) signaling to regulate MAPK/ERK, PI3K, TORC2/AKT, adenylyl cyclase and actin polymerization, which collectively direct chemotaxis. Upon ligand binding, mammalian GPCRs are phosphorylated at cytopl...

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Detalles Bibliográficos
Autores principales:	Brzostowski, Joseph A., Sawai, Satoshi, Rozov, Orr, Liao, Xin-hua, Imoto, Daisuke, Parent, Carole A., Kimmel, Alan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795335/ https://www.ncbi.nlm.nih.gov/pubmed/23902692 http://dx.doi.org/10.1242/jcs.122952

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