Cargando…

HEXIM1, a New Player in the p53 Pathway

Hexamethylene bisacetamide-inducible protein 1 (HEXIM1) is best known as the inhibitor of positive transcription elongation factor b (P-TEFb), which controls transcription elongation of RNA polymerase II and Tat transactivation of human immunodeficiency virus. Besides P-TEFb, several proteins have b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lew, Qiao Jing, Chu, Kai Ling, Chia, Yi Ling, Cheong, Nge, Chao, Sheng-Hao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2013
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795367/ https://www.ncbi.nlm.nih.gov/pubmed/24202322 http://dx.doi.org/10.3390/cancers5030838

Ejemplares similares

HEXIM1 Induces Differentiation of Human Pluripotent Stem Cells
por: Ding, Vanessa, et al.
Publicado: (2013)

Brd4 and HEXIM1: Multiple Roles in P-TEFb Regulation and Cancer
por: Chen, Ruichuan, et al.
Publicado: (2014)

Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy
por: Neo, Shu Hui, et al.
Publicado: (2015)

PKC phosphorylates HEXIM1 and regulates P-TEFb activity
por: Fujinaga, Koh, et al.
Publicado: (2012)

Inhibition of Tat activity by the HEXIM1 protein
por: Fraldi, Alessandro, et al.
Publicado: (2005)

HEXIM1 is a critical determinant of the response to tamoxifen
por: Ketchart, Wannarasmi, et al.
Publicado: (2011)

HEXIM1-Tat chimera inhibits HIV-1 replication
por: Leoz, Marie, et al.
Publicado: (2018)

HEXIM1 Peptide Exhibits Antimicrobial Activity Against Antibiotic Resistant Bacteria Through Guidance of Cell Penetrating Peptide
por: Ho, Pooi Leng, et al.
Publicado: (2019)

Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription
por: Barboric, Matjaz, et al.
Publicado: (2007)

HEXIM1 Diffusion in the Nucleus Is Regulated by Its Interactions with Both 7SK and P-TEFb
por: Furlan, Alessandro, et al.
Publicado: (2019)

Inhibition of metastasis by HEXIM1 through effects on cell invasion and angiogenesis
por: Ketchart, Wannarasmi, et al.
Publicado: (2012)

HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer
por: Shao, Hengyi, et al.
Publicado: (2020)

The Drosophila 7SK snRNP and the essential role of dHEXIM in development
por: Nguyen, Duy, et al.
Publicado: (2012)

Functional Interaction between HEXIM and Hedgehog Signaling during Drosophila Wing Development
por: Nguyen, Duy, et al.
Publicado: (2016)

Structural transitions in the RNA 7SK 5′ hairpin and their effect on HEXIM binding
por: Röder, Konstantin, et al.
Publicado: (2020)

Non-epigenetic induction of HEXIM1 by DNMT1 inhibitors and functional relevance
por: Sharma, Vikas, et al.
Publicado: (2020)

Ubenimex enhances Brd4 inhibition by suppressing HEXIM1 autophagic degradation and suppressing the Akt pathway in glioma cells
por: Han, Liping, et al.
Publicado: (2017)

Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb
por: Blazek, Dalibor, et al.
Publicado: (2005)

PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription
por: Lew, Qiao Jing, et al.
Publicado: (2011)

Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR
por: Sedore, Stanley C., et al.
Publicado: (2007)

Bovine HEXIM1 inhibits bovine immunodeficiency virus replication through regulating BTat-mediated transactivation
por: Guo, Hong-yan, et al.
Publicado: (2013)

GCN5 inhibits XBP-1S-mediated transcription by antagonizing PCAF action
por: Lew, Qiao Jing, et al.
Publicado: (2014)

BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication
por: Bowry, Akhil, et al.
Publicado: (2018)

Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells
por: Huang, Min, et al.
Publicado: (2016)

PHLD Class Proteins: A Family of New Players in the p53 Network
por: Fuselier, Taylor T., et al.
Publicado: (2020)

Acute hypoxia affects P-TEFb through HDAC3 and HEXIM1-dependent mechanism to promote gene-specific transcriptional repression
por: Safronova, Olga S., et al.
Publicado: (2014)

A Cyclin T1 point mutation that abolishes positive transcription elongation factor (P-TEFb) binding to Hexim1 and HIV tat
por: Verstraete, Nina, et al.
Publicado: (2014)

HEXIM1 induction is mechanistically involved in mediating anti-AML activity of BET protein bromodomain antagonist
por: Devaraj, Santhana G. T., et al.
Publicado: (2015)

A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA
por: Pham, Vincent V., et al.
Publicado: (2022)

HEXIM1 modulates vascular endothelial growth factor expression and function in breast epithelial cells and mammary gland
por: Ogba, Ndiya, et al.
Publicado: (2010)

Cardiomyocyte-Specific Overexpression of HEXIM1 Prevents Right Ventricular Hypertrophy in Hypoxia-Induced Pulmonary Hypertension in Mice
por: Yoshikawa, Noritada, et al.
Publicado: (2012)

Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats
por: Zhang, Kai-Kai, et al.
Publicado: (2021)

DEC1 and MIC-1: New players of p53-dependent cell fate decision
por: Qian, Yingjuan, et al.
Publicado: (2012)

HMBA Releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and Activates HIV Transcription
por: Contreras, Xavier, et al.
Publicado: (2007)

Tip110 Expression Facilitates the Release of HEXIM1 and pTEFb from the 7SK Ribonucleoprotein Complex Involving Regulation of the Intracellular Redox Level
por: Liu, Ying, et al.
Publicado: (2021)

HEXIM1 targets a repeated GAUC motif in the riboregulator of transcription 7SK and promotes base pair rearrangements
por: Lebars, Isabelle, et al.
Publicado: (2010)

CDK9 activity switch associated with AFF1 and HEXIM1 controls differentiation initiation from epidermal progenitors
por: Lloyd, Sarah M., et al.
Publicado: (2022)

OTUD5 Regulates p53 Stability by Deubiquitinating p53
por: Luo, Judong, et al.
Publicado: (2013)

Telomere Attrition and p53 Response 1 (TAPR1): a new player in cancer biology?
por: dos Santos, Gabriel Arantes, et al.
Publicado: (2021)

LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated
por: Krueger, Brian J., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_ecmvba620jd2777iu3b2jc4vdp