The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy

Bacterial nitroreductase enzymes that can efficiently catalyse the oxygen-independent reduction of prodrugs originally developed to target tumour hypoxia offer great potential for expanding the therapeutic range of these molecules to aerobic tumour regions, via the emerging cancer strategy of gene-d...

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Detalles Bibliográficos
Autores principales: Green, Laura K., Storey, Mathew A., Williams, Elsie M., Patterson, Adam V., Smaill, Jeff B., Copp, Janine N., Ackerley, David F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795375/
https://www.ncbi.nlm.nih.gov/pubmed/24202330
http://dx.doi.org/10.3390/cancers5030985

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