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Primary Monophasic Synovial Sarcoma of the Kidney: A Case Report and Review of Literature

Primary synovial sarcoma (SS) of the kidney is a rare neoplasm and its presenting features are similar to other common renal tumors, making early diagnosis difficult. To date, few cases have been reported in the literature. Primary renal SSs can exist in either a monophasic or a biphasic pattern, th...

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Autores principales: Lopes, Henrique, Pereira, Caio A.D., Zucca, Luís E.R., Serrano, Sérgio V., Silva, Sandra R.M., Camparoto, Marjori L., Cárcano, Flavio M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795529/
https://www.ncbi.nlm.nih.gov/pubmed/24137053
http://dx.doi.org/10.4137/CMO.S12243
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author Lopes, Henrique
Pereira, Caio A.D.
Zucca, Luís E.R.
Serrano, Sérgio V.
Silva, Sandra R.M.
Camparoto, Marjori L.
Cárcano, Flavio M.
author_facet Lopes, Henrique
Pereira, Caio A.D.
Zucca, Luís E.R.
Serrano, Sérgio V.
Silva, Sandra R.M.
Camparoto, Marjori L.
Cárcano, Flavio M.
author_sort Lopes, Henrique
collection PubMed
description Primary synovial sarcoma (SS) of the kidney is a rare neoplasm and its presenting features are similar to other common renal tumors, making early diagnosis difficult. To date, few cases have been reported in the literature. Primary renal SSs can exist in either a monophasic or a biphasic pattern, the former being more common and tending to have a better prognosis than the biphasic variant. Herein we describe a case of primary renal SS that was diagnosed based on histopathology and immunohistochemistry after radical nephrectomy. Fusion gene product analysis was also done by FISH and RT-PCR. Patient follow-up and literature review are presented, focused on systemic therapy. We highlight that these tumors should be correctly diagnosed as clinical results and specific treatment are distinct from primary epithelial renal cell carcinoma. Adjuvant chemotherapy should be tailored for each patient in the management of disease, although its role still remains unclear.
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spelling pubmed-37955292013-10-17 Primary Monophasic Synovial Sarcoma of the Kidney: A Case Report and Review of Literature Lopes, Henrique Pereira, Caio A.D. Zucca, Luís E.R. Serrano, Sérgio V. Silva, Sandra R.M. Camparoto, Marjori L. Cárcano, Flavio M. Clin Med Insights Oncol Case Report Primary synovial sarcoma (SS) of the kidney is a rare neoplasm and its presenting features are similar to other common renal tumors, making early diagnosis difficult. To date, few cases have been reported in the literature. Primary renal SSs can exist in either a monophasic or a biphasic pattern, the former being more common and tending to have a better prognosis than the biphasic variant. Herein we describe a case of primary renal SS that was diagnosed based on histopathology and immunohistochemistry after radical nephrectomy. Fusion gene product analysis was also done by FISH and RT-PCR. Patient follow-up and literature review are presented, focused on systemic therapy. We highlight that these tumors should be correctly diagnosed as clinical results and specific treatment are distinct from primary epithelial renal cell carcinoma. Adjuvant chemotherapy should be tailored for each patient in the management of disease, although its role still remains unclear. Libertas Academica 2013-10-07 /pmc/articles/PMC3795529/ /pubmed/24137053 http://dx.doi.org/10.4137/CMO.S12243 Text en © 2013 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article published under the Creative Commons CC-BY-NC 3.0 license.
spellingShingle Case Report
Lopes, Henrique
Pereira, Caio A.D.
Zucca, Luís E.R.
Serrano, Sérgio V.
Silva, Sandra R.M.
Camparoto, Marjori L.
Cárcano, Flavio M.
Primary Monophasic Synovial Sarcoma of the Kidney: A Case Report and Review of Literature
title Primary Monophasic Synovial Sarcoma of the Kidney: A Case Report and Review of Literature
title_full Primary Monophasic Synovial Sarcoma of the Kidney: A Case Report and Review of Literature
title_fullStr Primary Monophasic Synovial Sarcoma of the Kidney: A Case Report and Review of Literature
title_full_unstemmed Primary Monophasic Synovial Sarcoma of the Kidney: A Case Report and Review of Literature
title_short Primary Monophasic Synovial Sarcoma of the Kidney: A Case Report and Review of Literature
title_sort primary monophasic synovial sarcoma of the kidney: a case report and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795529/
https://www.ncbi.nlm.nih.gov/pubmed/24137053
http://dx.doi.org/10.4137/CMO.S12243
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