High-resolution crystal structure of Streptococcus pyogenes β-NAD(+) glycohydrolase in complex with its endogenous inhibitor IFS reveals a highly water-rich interface

One of the virulence factors produced by Streptococcus pyogenes is β-NAD(+) glycohydrolase (SPN). S. pyogenes injects SPN into the cytosol of an infected host cell using the cytolysin-mediated translocation pathway. As SPN is toxic to bacterial cells themselves, S. pyogenes possesses the ifs gene th...

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Detalles Bibliográficos
Autores principales: Yoon, Ji Young, An, Doo Ri, Yoon, Hye-Jin, Kim, Hyoun Sook, Lee, Sang Jae, Im, Ha Na, Jang, Jun Young, Suh, Se Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2013
Materias:
Diffraction Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795565/
https://www.ncbi.nlm.nih.gov/pubmed/24121349
http://dx.doi.org/10.1107/S0909049513020803

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