Alpha-Helical Destabilization of the Bcl-2-BH4-Domain Peptide Abolishes Its Ability to Inhibit the IP(3) Receptor

The anti-apoptotic Bcl-2 protein is the founding member and namesake of the Bcl-2-protein family. It has recently been demonstrated that Bcl-2, apart from its anti-apoptotic role at mitochondrial membranes, can also directly interact with the inositol 1,4,5-trisphosphate receptor (IP(3)R), the prima...

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Detalles Bibliográficos
Autores principales: Monaco, Giovanni, Decrock, Elke, Nuyts, Koen, Wagner II, Larry E., Luyten, Tomas, Strelkov, Sergei V., Missiaen, Ludwig, De Borggraeve, Wim M., Leybaert, Luc, Yule, David I., De Smedt, Humbert, Parys, Jan B., Bultynck, Geert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795776/
https://www.ncbi.nlm.nih.gov/pubmed/24137498
http://dx.doi.org/10.1371/journal.pone.0073386

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