A liver HIF-2α/IRS2 pathway sensitizes hepatic insulin signaling and is modulated by VEGF inhibition

Insulin initiates diverse hepatic metabolic responses, including gluconeogenic suppression and induction of glycogen synthesis and lipogenesis(1,2). The liver possesses a rich sinusoidal capillary network with increased hypoxia and decreased gluconeogenesis in the perivenous zone(3). Here, diverse v...

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Detalles Bibliográficos
Autores principales: Wei, Kevin, Piecewicz, Stephanie M., McGinnis, Lisa M., Taniguchi, Cullen M., Wiegand, Stanley J., Anderson, Keith, Chan, Carol W-M., Mulligan, Kimberly X., Kuo, David, Yuan, Jenny, Vallon, Mario, Morton, Lori, Lefai, Etienne, Simon, M. Celeste, Maher, Jacquelyn J., Mithieux, Gilles, Rajas, Fabienne, Annes, Justin, McGuinness, Owen P., Thurston, Gavin, Giaccia, Amato J., Kuo, Calvin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795838/
https://www.ncbi.nlm.nih.gov/pubmed/24037094
http://dx.doi.org/10.1038/nm.3295

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