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Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor
Endothelial secretion of von Willebrand factor (VWF) from intracellular organelles known as Weibel-Palade bodies (WPBs) is required for platelet adhesion to the injured vessel wall. Here, we demonstrate that WPBs are in some cases found near or within autophagosomes and that endothelial autophagosom...
Autores principales: | Torisu, Takehiro, Torisu, Kumiko, Lee, In Hye, Liu, Jie, Malide, Daniela, Combs, Christian A., Wu, Xufeng S., Rovira, Ilsa I., Fergusson, Maria M., Weigert, Roberto, Connelly, Patricia S., Daniels, Mathew P, Komatsu, Masaaki, Cao, Liu, Finkel, Toren |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795899/ https://www.ncbi.nlm.nih.gov/pubmed/24056772 http://dx.doi.org/10.1038/nm.3288 |
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