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Rapamycin extends life- and health span because it slows aging

Making headlines, a thought-provocative paper by Neff, Ehninger and coworkers claims that rapamycin extends life span but has limited effects on aging. How is that possibly possible? And what is aging if not an increase of the probability of death with age. I discuss that the JCI paper actually show...

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Autor principal: Blagosklonny, Mikhail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796212/
https://www.ncbi.nlm.nih.gov/pubmed/23934728
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author Blagosklonny, Mikhail V.
author_facet Blagosklonny, Mikhail V.
author_sort Blagosklonny, Mikhail V.
collection PubMed
description Making headlines, a thought-provocative paper by Neff, Ehninger and coworkers claims that rapamycin extends life span but has limited effects on aging. How is that possibly possible? And what is aging if not an increase of the probability of death with age. I discuss that the JCI paper actually shows that rapamycin slows aging and also extends lifespan regardless of its direct anti-cancer activities. Aging is, in part, MTOR-driven: a purposeless continuation of developmental growth. Rapamycin affects the same processes in young and old animals: young animals' traits and phenotypes, which continuations become hyperfunctional, harmful and lethal later in life.
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spelling pubmed-37962122013-10-15 Rapamycin extends life- and health span because it slows aging Blagosklonny, Mikhail V. Aging (Albany NY) Research Perspective Making headlines, a thought-provocative paper by Neff, Ehninger and coworkers claims that rapamycin extends life span but has limited effects on aging. How is that possibly possible? And what is aging if not an increase of the probability of death with age. I discuss that the JCI paper actually shows that rapamycin slows aging and also extends lifespan regardless of its direct anti-cancer activities. Aging is, in part, MTOR-driven: a purposeless continuation of developmental growth. Rapamycin affects the same processes in young and old animals: young animals' traits and phenotypes, which continuations become hyperfunctional, harmful and lethal later in life. Impact Journals LLC 2013-08-11 /pmc/articles/PMC3796212/ /pubmed/23934728 Text en Copyright: © 2013 Blagosklonny http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspective
Blagosklonny, Mikhail V.
Rapamycin extends life- and health span because it slows aging
title Rapamycin extends life- and health span because it slows aging
title_full Rapamycin extends life- and health span because it slows aging
title_fullStr Rapamycin extends life- and health span because it slows aging
title_full_unstemmed Rapamycin extends life- and health span because it slows aging
title_short Rapamycin extends life- and health span because it slows aging
title_sort rapamycin extends life- and health span because it slows aging
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796212/
https://www.ncbi.nlm.nih.gov/pubmed/23934728
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