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Rapamycin extends life- and health span because it slows aging
Making headlines, a thought-provocative paper by Neff, Ehninger and coworkers claims that rapamycin extends life span but has limited effects on aging. How is that possibly possible? And what is aging if not an increase of the probability of death with age. I discuss that the JCI paper actually show...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Impact Journals LLC
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796212/ https://www.ncbi.nlm.nih.gov/pubmed/23934728 |
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author | Blagosklonny, Mikhail V. |
author_facet | Blagosklonny, Mikhail V. |
author_sort | Blagosklonny, Mikhail V. |
collection | PubMed |
description | Making headlines, a thought-provocative paper by Neff, Ehninger and coworkers claims that rapamycin extends life span but has limited effects on aging. How is that possibly possible? And what is aging if not an increase of the probability of death with age. I discuss that the JCI paper actually shows that rapamycin slows aging and also extends lifespan regardless of its direct anti-cancer activities. Aging is, in part, MTOR-driven: a purposeless continuation of developmental growth. Rapamycin affects the same processes in young and old animals: young animals' traits and phenotypes, which continuations become hyperfunctional, harmful and lethal later in life. |
format | Online Article Text |
id | pubmed-3796212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-37962122013-10-15 Rapamycin extends life- and health span because it slows aging Blagosklonny, Mikhail V. Aging (Albany NY) Research Perspective Making headlines, a thought-provocative paper by Neff, Ehninger and coworkers claims that rapamycin extends life span but has limited effects on aging. How is that possibly possible? And what is aging if not an increase of the probability of death with age. I discuss that the JCI paper actually shows that rapamycin slows aging and also extends lifespan regardless of its direct anti-cancer activities. Aging is, in part, MTOR-driven: a purposeless continuation of developmental growth. Rapamycin affects the same processes in young and old animals: young animals' traits and phenotypes, which continuations become hyperfunctional, harmful and lethal later in life. Impact Journals LLC 2013-08-11 /pmc/articles/PMC3796212/ /pubmed/23934728 Text en Copyright: © 2013 Blagosklonny http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
spellingShingle | Research Perspective Blagosklonny, Mikhail V. Rapamycin extends life- and health span because it slows aging |
title | Rapamycin extends life- and health span because it slows aging |
title_full | Rapamycin extends life- and health span because it slows aging |
title_fullStr | Rapamycin extends life- and health span because it slows aging |
title_full_unstemmed | Rapamycin extends life- and health span because it slows aging |
title_short | Rapamycin extends life- and health span because it slows aging |
title_sort | rapamycin extends life- and health span because it slows aging |
topic | Research Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796212/ https://www.ncbi.nlm.nih.gov/pubmed/23934728 |
work_keys_str_mv | AT blagosklonnymikhailv rapamycinextendslifeandhealthspanbecauseitslowsaging |