Alloreactivity of Virus-Specific T Cells: Possible Implication of Graft-Versus-Host Disease and Graft-Versus-Leukemia Effects

Immune reconstitution of functional virus-specific T cells after allogeneic hematopoietic stem cell transplantation (HSCT) has been intensively investigated. However, the possible role of crossreactivity of these virus-specific T cells against allogeneic targets is still unclear. Theoretically, as i...

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Autores principales: Fuji, Shigeo, Kapp, Markus, Einsele, Hermann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796284/
https://www.ncbi.nlm.nih.gov/pubmed/24133497
http://dx.doi.org/10.3389/fimmu.2013.00330
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author Fuji, Shigeo
Kapp, Markus
Einsele, Hermann
author_facet Fuji, Shigeo
Kapp, Markus
Einsele, Hermann
author_sort Fuji, Shigeo
collection PubMed
description Immune reconstitution of functional virus-specific T cells after allogeneic hematopoietic stem cell transplantation (HSCT) has been intensively investigated. However, the possible role of crossreactivity of these virus-specific T cells against allogeneic targets is still unclear. Theoretically, as in the field of organ transplantation, virus-specific T cells possess crossreactivity potential after allogeneic HSCT. Such crossreactivity is assumed to play a role in graft-versus-host disease and graft-versus-leukemia effects. In this article, we aim to give a comprehensive overview of current understanding about crossreactivity of virus-specific T cells.
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spelling pubmed-37962842013-10-16 Alloreactivity of Virus-Specific T Cells: Possible Implication of Graft-Versus-Host Disease and Graft-Versus-Leukemia Effects Fuji, Shigeo Kapp, Markus Einsele, Hermann Front Immunol Immunology Immune reconstitution of functional virus-specific T cells after allogeneic hematopoietic stem cell transplantation (HSCT) has been intensively investigated. However, the possible role of crossreactivity of these virus-specific T cells against allogeneic targets is still unclear. Theoretically, as in the field of organ transplantation, virus-specific T cells possess crossreactivity potential after allogeneic HSCT. Such crossreactivity is assumed to play a role in graft-versus-host disease and graft-versus-leukemia effects. In this article, we aim to give a comprehensive overview of current understanding about crossreactivity of virus-specific T cells. Frontiers Media S.A. 2013-10-14 /pmc/articles/PMC3796284/ /pubmed/24133497 http://dx.doi.org/10.3389/fimmu.2013.00330 Text en Copyright © 2013 Fuji, Kapp and Einsele. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Fuji, Shigeo
Kapp, Markus
Einsele, Hermann
Alloreactivity of Virus-Specific T Cells: Possible Implication of Graft-Versus-Host Disease and Graft-Versus-Leukemia Effects
title Alloreactivity of Virus-Specific T Cells: Possible Implication of Graft-Versus-Host Disease and Graft-Versus-Leukemia Effects
title_full Alloreactivity of Virus-Specific T Cells: Possible Implication of Graft-Versus-Host Disease and Graft-Versus-Leukemia Effects
title_fullStr Alloreactivity of Virus-Specific T Cells: Possible Implication of Graft-Versus-Host Disease and Graft-Versus-Leukemia Effects
title_full_unstemmed Alloreactivity of Virus-Specific T Cells: Possible Implication of Graft-Versus-Host Disease and Graft-Versus-Leukemia Effects
title_short Alloreactivity of Virus-Specific T Cells: Possible Implication of Graft-Versus-Host Disease and Graft-Versus-Leukemia Effects
title_sort alloreactivity of virus-specific t cells: possible implication of graft-versus-host disease and graft-versus-leukemia effects
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796284/
https://www.ncbi.nlm.nih.gov/pubmed/24133497
http://dx.doi.org/10.3389/fimmu.2013.00330
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