PF-03882845, a non-steroidal mineralocorticoid receptor antagonist, prevents renal injury with reduced risk of hyperkalemia in an animal model of nephropathy

The mineralocorticoid receptor (MR) antagonists PF-03882845 and eplerenone were evaluated for renal protection against aldosterone-mediated renal disease in uninephrectomized Sprague-Dawley (SD) rats maintained on a high salt diet and receiving aldosterone by osmotic mini-pump for 27 days. Serum K(+...

Descripción completa

Detalles Bibliográficos
Autores principales: Orena, Stephen, Maurer, Tristan S., She, Li, Eudy, Rena, Bernardo, Vincent, Dash, Darla, Loria, Paula, Banker, Mary E., Tugnait, Meera, Okerberg, Carlin V., Qian, Jessie, Boustany-Kari, Carine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796291/
https://www.ncbi.nlm.nih.gov/pubmed/24133446
http://dx.doi.org/10.3389/fphar.2013.00115

Ejemplares similares

Ejemplares similares