A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis

mir-17-92, a potent polycistronic oncomir, encodes six mature miRNAs with complex modes of interactions. In the Eμ-myc Burkitt’s lymphoma model, mir-17-92 exhibits potent oncogenic activity by repressing c-Myc-induced apoptosis, primarily through its miR-19 components. Surprisingly, mir-17-92 also e...

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Detalles Bibliográficos
Autores principales: Olive, Virginie, Sabio, Erich, Bennett, Margaux J, De Jong, Caitlin S, Biton, Anne, McGann, James C, Greaney, Samantha K, Sodir, Nicole M, Zhou, Alicia Y, Balakrishnan, Asha, Foth, Mona, Luftig, Micah A, Goga, Andrei, Speed, Terence P, Xuan, Zhenyu, Evan, Gerard I, Wan, Ying, Minella, Alex C, He, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796314/
https://www.ncbi.nlm.nih.gov/pubmed/24137534
http://dx.doi.org/10.7554/eLife.00822

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