SUMOylation in Trypanosoma brucei

Small ubiquitin like modifier (SUMO) proteins are involved in many processes in eukaryotes. We here show that Trypanosoma brucei SUMO (Tb927.5.3210) modifies many proteins. The levels of SUMOylation were unaffected by temperature changes but were increased by severe oxidative stress. We obtained evi...

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Detalles Bibliográficos
Autores principales: Klein, Cornelia Andrea, Droll, Dorothea, Clayton, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2013
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796365/
https://www.ncbi.nlm.nih.gov/pubmed/24133638
http://dx.doi.org/10.7717/peerj.180
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author Klein, Cornelia Andrea
Droll, Dorothea
Clayton, Christine
author_facet Klein, Cornelia Andrea
Droll, Dorothea
Clayton, Christine
author_sort Klein, Cornelia Andrea
collection PubMed
description Small ubiquitin like modifier (SUMO) proteins are involved in many processes in eukaryotes. We here show that Trypanosoma brucei SUMO (Tb927.5.3210) modifies many proteins. The levels of SUMOylation were unaffected by temperature changes but were increased by severe oxidative stress. We obtained evidence that trypanosome homologues of the SUMO conjugating enzyme Ubc9 (Tb927.2.2460) and the SUMO-specific protease SENP (Tb927.9.2220) are involved in SUMOylation and SUMO removal, respectively.
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spelling pubmed-37963652013-10-16 SUMOylation in Trypanosoma brucei Klein, Cornelia Andrea Droll, Dorothea Clayton, Christine PeerJ Cell Biology Small ubiquitin like modifier (SUMO) proteins are involved in many processes in eukaryotes. We here show that Trypanosoma brucei SUMO (Tb927.5.3210) modifies many proteins. The levels of SUMOylation were unaffected by temperature changes but were increased by severe oxidative stress. We obtained evidence that trypanosome homologues of the SUMO conjugating enzyme Ubc9 (Tb927.2.2460) and the SUMO-specific protease SENP (Tb927.9.2220) are involved in SUMOylation and SUMO removal, respectively. PeerJ Inc. 2013-10-08 /pmc/articles/PMC3796365/ /pubmed/24133638 http://dx.doi.org/10.7717/peerj.180 Text en © 2013 Klein et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cell Biology
Klein, Cornelia Andrea
Droll, Dorothea
Clayton, Christine
SUMOylation in Trypanosoma brucei
title SUMOylation in Trypanosoma brucei
title_full SUMOylation in Trypanosoma brucei
title_fullStr SUMOylation in Trypanosoma brucei
title_full_unstemmed SUMOylation in Trypanosoma brucei
title_short SUMOylation in Trypanosoma brucei
title_sort sumoylation in trypanosoma brucei
topic Cell Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796365/
https://www.ncbi.nlm.nih.gov/pubmed/24133638
http://dx.doi.org/10.7717/peerj.180
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AT drolldorothea sumoylationintrypanosomabrucei
AT claytonchristine sumoylationintrypanosomabrucei

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