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Two rare cases of a solid pseudopapillary neoplasm of the pancreas
A solid pseudopapillary neoplasm (SPN) of the pancreas has distinct histopathological features. A solid pattern of growth with pseudopapillary structures that result from degeneration is observed. On rare occasions, the tumor may vary from being entirely solid to completely cystic. The present study...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796422/ https://www.ncbi.nlm.nih.gov/pubmed/24137427 http://dx.doi.org/10.3892/ol.2013.1476 |
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author | SAIGO, CHIEMI HIROSE, YOSHINOBU ASANO, NAMI TAKAMATSU, MANABU FUKUSHIMA, NORIYOSHI YASUDA, ICHIRO GOSHIMA, SATOSHI OZEKI, MICHIO OSADA, SHINJI |
author_facet | SAIGO, CHIEMI HIROSE, YOSHINOBU ASANO, NAMI TAKAMATSU, MANABU FUKUSHIMA, NORIYOSHI YASUDA, ICHIRO GOSHIMA, SATOSHI OZEKI, MICHIO OSADA, SHINJI |
author_sort | SAIGO, CHIEMI |
collection | PubMed |
description | A solid pseudopapillary neoplasm (SPN) of the pancreas has distinct histopathological features. A solid pattern of growth with pseudopapillary structures that result from degeneration is observed. On rare occasions, the tumor may vary from being entirely solid to completely cystic. The present study describes two unique cases of SPN. A 25-year-old male presented with a pancreatic tumor showing a predominantly solid pattern with no degenerative change, although the pre-operative cytological specimens that were obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) revealed pseudopapillary structures. The second case was of an 11-year-old female who presented with a pancreatic tumor with prominent degeneration. Nests and cords of the remaining neoplastic cells were located only at the periphery, with perineural invasion. An immunohistochemical analysis revealed that the tumor cells in the two cases were positive for CD10 and β-catenin and negative for trypsin. An awareness of the broad morphological variability of SPN and an immunohistochemical panel that includes CD10, β-catenin and trypsin are useful for establishing an accurate diagnosis. |
format | Online Article Text |
id | pubmed-3796422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-37964222013-10-17 Two rare cases of a solid pseudopapillary neoplasm of the pancreas SAIGO, CHIEMI HIROSE, YOSHINOBU ASANO, NAMI TAKAMATSU, MANABU FUKUSHIMA, NORIYOSHI YASUDA, ICHIRO GOSHIMA, SATOSHI OZEKI, MICHIO OSADA, SHINJI Oncol Lett Articles A solid pseudopapillary neoplasm (SPN) of the pancreas has distinct histopathological features. A solid pattern of growth with pseudopapillary structures that result from degeneration is observed. On rare occasions, the tumor may vary from being entirely solid to completely cystic. The present study describes two unique cases of SPN. A 25-year-old male presented with a pancreatic tumor showing a predominantly solid pattern with no degenerative change, although the pre-operative cytological specimens that were obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) revealed pseudopapillary structures. The second case was of an 11-year-old female who presented with a pancreatic tumor with prominent degeneration. Nests and cords of the remaining neoplastic cells were located only at the periphery, with perineural invasion. An immunohistochemical analysis revealed that the tumor cells in the two cases were positive for CD10 and β-catenin and negative for trypsin. An awareness of the broad morphological variability of SPN and an immunohistochemical panel that includes CD10, β-catenin and trypsin are useful for establishing an accurate diagnosis. D.A. Spandidos 2013-10 2013-07-19 /pmc/articles/PMC3796422/ /pubmed/24137427 http://dx.doi.org/10.3892/ol.2013.1476 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles SAIGO, CHIEMI HIROSE, YOSHINOBU ASANO, NAMI TAKAMATSU, MANABU FUKUSHIMA, NORIYOSHI YASUDA, ICHIRO GOSHIMA, SATOSHI OZEKI, MICHIO OSADA, SHINJI Two rare cases of a solid pseudopapillary neoplasm of the pancreas |
title | Two rare cases of a solid pseudopapillary neoplasm of the pancreas |
title_full | Two rare cases of a solid pseudopapillary neoplasm of the pancreas |
title_fullStr | Two rare cases of a solid pseudopapillary neoplasm of the pancreas |
title_full_unstemmed | Two rare cases of a solid pseudopapillary neoplasm of the pancreas |
title_short | Two rare cases of a solid pseudopapillary neoplasm of the pancreas |
title_sort | two rare cases of a solid pseudopapillary neoplasm of the pancreas |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796422/ https://www.ncbi.nlm.nih.gov/pubmed/24137427 http://dx.doi.org/10.3892/ol.2013.1476 |
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