Improved PCR Performance Using Template DNA from Formalin-Fixed and Paraffin-Embedded Tissues by Overcoming PCR Inhibition

Formalin-fixed and paraffin-embedded (FFPE) tissues represent a valuable source for biomarker studies and clinical routine diagnostics. However, they suffer from degradation of nucleic acids due to the fixation process. Since genetic and epigenetic studies usually require PCR amplification, this deg...

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Detalles Bibliográficos
Autores principales: Dietrich, Dimo, Uhl, Barbara, Sailer, Verena, Holmes, Emily Eva, Jung, Maria, Meller, Sebastian, Kristiansen, Glen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796491/
https://www.ncbi.nlm.nih.gov/pubmed/24155973
http://dx.doi.org/10.1371/journal.pone.0077771

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