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IL-27 Enhances the Expression of TRAIL and TLR3 in Human Melanomas and Inhibits Their Tumor Growth in Cooperation with a TLR3 Agonist Poly(I:C) Partly in a TRAIL-Dependent Manner
Interleukin (IL)-27 is a member of the IL-6/IL-12 cytokine family and possesses potent antitumor activity, which is mediated by multiple mechanisms. Toll-like receptor (TLR)3 is the critical sensor of the innate immune system that serves to identify viral double-stranded RNA. TLR3 is frequently expr...
Autores principales: | Chiba, Yukino, Mizoguchi, Izuru, Mitobe, Kana, Higuchi, Kaname, Nagai, Hiroshi, Nishigori, Chikako, Mizuguchi, Junichiro, Yoshimoto, Takayuki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796519/ https://www.ncbi.nlm.nih.gov/pubmed/24155891 http://dx.doi.org/10.1371/journal.pone.0076159 |
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