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Evidence Supporting a Role for Mammalian Chitinases in Efficacy of Caspofungin against Experimental Aspergillosis in Immunocompromised Rats

OBJECTIVES: Caspofungin, currently used as salvage therapy for invasive pulmonary aspergillosis (IPA), strangely only causes morphological changes in fungal growth in vitro but does not inhibit the growth. In vivo it has good efficacy. Therefore the question arises how this in vivo activity is reach...

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Detalles Bibliográficos
Autores principales:	Verwer, Patricia E. B., ten Kate, Marian T., Falcone, Franco H., Morroll, Shaun, Verbrugh, Henri A., Bakker-Woudenberg, Irma A. J. M., van de Sande, Wendy W. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796522/ https://www.ncbi.nlm.nih.gov/pubmed/24155872 http://dx.doi.org/10.1371/journal.pone.0075848

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