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Protein-Protein Interactions as a Strategy towards Protein-Specific Drug Design: The Example of Ataxin-1
A main challenge for structural biologists is to understand the mechanisms that discriminate between molecular interactions and determine function. Here, we show how partner recognition of the AXH domain of the transcriptional co-regulator ataxin-1 is fine-tuned by a subtle balance between self- and...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796545/ https://www.ncbi.nlm.nih.gov/pubmed/24155902 http://dx.doi.org/10.1371/journal.pone.0076456 |