Cargando…

Serum 2,3,7,8-Tetrachlorodibenzo-p-dioxin Levels and Their Association With Age, Body Mass Index, Smoking, Military Record-based Variables, and Estimated Exposure to Agent Orange in Korean Vietnam Veterans

OBJECTIVES: The aim of this study was to examine the levels of serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and evaluate their association with age, body mass index, smoking, military record-based variables, and estimated exposure to Agent Orange in Korean Vietnam veterans. METHODS: Serum levels...

Descripción completa

Detalles Bibliográficos
Autores principales: Yi, Sang-Wook, Ohrr, Heechoul, Won, Jong-Uk, Song, Jae-Seok, Hong, Jae-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Preventive Medicine 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796648/
https://www.ncbi.nlm.nih.gov/pubmed/24137525
http://dx.doi.org/10.3961/jpmph.2013.46.5.226
_version_ 1782287514287996928
author Yi, Sang-Wook
Ohrr, Heechoul
Won, Jong-Uk
Song, Jae-Seok
Hong, Jae-Seok
author_facet Yi, Sang-Wook
Ohrr, Heechoul
Won, Jong-Uk
Song, Jae-Seok
Hong, Jae-Seok
author_sort Yi, Sang-Wook
collection PubMed
description OBJECTIVES: The aim of this study was to examine the levels of serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and evaluate their association with age, body mass index, smoking, military record-based variables, and estimated exposure to Agent Orange in Korean Vietnam veterans. METHODS: Serum levels of TCDD were analyzed in 102 Vietnam veterans. Information on age, body mass index, and smoking status were obtained from a self-reported questionnaire. The perceived exposure was assessed by a 6-item questionnaire. Two proximity-based exposures were constructed by division/brigade level and battalion/company level unit information using the Stellman exposure opportunity index model. RESULTS: The mean and median of serum TCDD levels was 1.2 parts per trillion (ppt) and 0.9 ppt, respectively. Only 2 Vietnam veterans had elevated levels of TCDD (>10 ppt). The levels of TCDD did not tend to increase with the likelihood of exposure to Agent Orange, as estimated from either proximity-based exposure or perceived self-reported exposure. The serum TCDD levels were not significantly different according to military unit, year of first deployment, duration of deployment, military rank, age, body mass index, and smoking status. CONCLUSIONS: The average serum TCDD levels in the Korean Vietnam veterans were lower than those reported for other occupationally or environmentally exposed groups and US Vietnam veterans, and their use as an objective marker of Agent Orange exposure may have some limitations. The unit of deployment, duration of deployment, year of first deployment, military rank, perceived self-reported exposure, and proximity-based exposure to Agent Orange were not associated with TCDD levels in Korean Vietnam veterans. Age, body mass index and smoking also were not associated with TCDD levels.
format Online
Article
Text
id pubmed-3796648
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher The Korean Society for Preventive Medicine
record_format MEDLINE/PubMed
spelling pubmed-37966482013-10-17 Serum 2,3,7,8-Tetrachlorodibenzo-p-dioxin Levels and Their Association With Age, Body Mass Index, Smoking, Military Record-based Variables, and Estimated Exposure to Agent Orange in Korean Vietnam Veterans Yi, Sang-Wook Ohrr, Heechoul Won, Jong-Uk Song, Jae-Seok Hong, Jae-Seok J Prev Med Public Health Original Article OBJECTIVES: The aim of this study was to examine the levels of serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and evaluate their association with age, body mass index, smoking, military record-based variables, and estimated exposure to Agent Orange in Korean Vietnam veterans. METHODS: Serum levels of TCDD were analyzed in 102 Vietnam veterans. Information on age, body mass index, and smoking status were obtained from a self-reported questionnaire. The perceived exposure was assessed by a 6-item questionnaire. Two proximity-based exposures were constructed by division/brigade level and battalion/company level unit information using the Stellman exposure opportunity index model. RESULTS: The mean and median of serum TCDD levels was 1.2 parts per trillion (ppt) and 0.9 ppt, respectively. Only 2 Vietnam veterans had elevated levels of TCDD (>10 ppt). The levels of TCDD did not tend to increase with the likelihood of exposure to Agent Orange, as estimated from either proximity-based exposure or perceived self-reported exposure. The serum TCDD levels were not significantly different according to military unit, year of first deployment, duration of deployment, military rank, age, body mass index, and smoking status. CONCLUSIONS: The average serum TCDD levels in the Korean Vietnam veterans were lower than those reported for other occupationally or environmentally exposed groups and US Vietnam veterans, and their use as an objective marker of Agent Orange exposure may have some limitations. The unit of deployment, duration of deployment, year of first deployment, military rank, perceived self-reported exposure, and proximity-based exposure to Agent Orange were not associated with TCDD levels in Korean Vietnam veterans. Age, body mass index and smoking also were not associated with TCDD levels. The Korean Society for Preventive Medicine 2013-09 2013-09-30 /pmc/articles/PMC3796648/ /pubmed/24137525 http://dx.doi.org/10.3961/jpmph.2013.46.5.226 Text en Copyright © 2013 The Korean Society for Preventive Medicine http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yi, Sang-Wook
Ohrr, Heechoul
Won, Jong-Uk
Song, Jae-Seok
Hong, Jae-Seok
Serum 2,3,7,8-Tetrachlorodibenzo-p-dioxin Levels and Their Association With Age, Body Mass Index, Smoking, Military Record-based Variables, and Estimated Exposure to Agent Orange in Korean Vietnam Veterans
title Serum 2,3,7,8-Tetrachlorodibenzo-p-dioxin Levels and Their Association With Age, Body Mass Index, Smoking, Military Record-based Variables, and Estimated Exposure to Agent Orange in Korean Vietnam Veterans
title_full Serum 2,3,7,8-Tetrachlorodibenzo-p-dioxin Levels and Their Association With Age, Body Mass Index, Smoking, Military Record-based Variables, and Estimated Exposure to Agent Orange in Korean Vietnam Veterans
title_fullStr Serum 2,3,7,8-Tetrachlorodibenzo-p-dioxin Levels and Their Association With Age, Body Mass Index, Smoking, Military Record-based Variables, and Estimated Exposure to Agent Orange in Korean Vietnam Veterans
title_full_unstemmed Serum 2,3,7,8-Tetrachlorodibenzo-p-dioxin Levels and Their Association With Age, Body Mass Index, Smoking, Military Record-based Variables, and Estimated Exposure to Agent Orange in Korean Vietnam Veterans
title_short Serum 2,3,7,8-Tetrachlorodibenzo-p-dioxin Levels and Their Association With Age, Body Mass Index, Smoking, Military Record-based Variables, and Estimated Exposure to Agent Orange in Korean Vietnam Veterans
title_sort serum 2,3,7,8-tetrachlorodibenzo-p-dioxin levels and their association with age, body mass index, smoking, military record-based variables, and estimated exposure to agent orange in korean vietnam veterans
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796648/
https://www.ncbi.nlm.nih.gov/pubmed/24137525
http://dx.doi.org/10.3961/jpmph.2013.46.5.226
work_keys_str_mv AT yisangwook serum2378tetrachlorodibenzopdioxinlevelsandtheirassociationwithagebodymassindexsmokingmilitaryrecordbasedvariablesandestimatedexposuretoagentorangeinkoreanvietnamveterans
AT ohrrheechoul serum2378tetrachlorodibenzopdioxinlevelsandtheirassociationwithagebodymassindexsmokingmilitaryrecordbasedvariablesandestimatedexposuretoagentorangeinkoreanvietnamveterans
AT wonjonguk serum2378tetrachlorodibenzopdioxinlevelsandtheirassociationwithagebodymassindexsmokingmilitaryrecordbasedvariablesandestimatedexposuretoagentorangeinkoreanvietnamveterans
AT songjaeseok serum2378tetrachlorodibenzopdioxinlevelsandtheirassociationwithagebodymassindexsmokingmilitaryrecordbasedvariablesandestimatedexposuretoagentorangeinkoreanvietnamveterans
AT hongjaeseok serum2378tetrachlorodibenzopdioxinlevelsandtheirassociationwithagebodymassindexsmokingmilitaryrecordbasedvariablesandestimatedexposuretoagentorangeinkoreanvietnamveterans