Mammalian ribosomal and chaperone protein RPS3A counteracts α-synuclein aggregation and toxicity in a yeast model system

Accumulation of aggregated forms of αSyn (α-synuclein) into Lewy bodies is a known hallmark associated with neuronal cell death in Parkinson's disease. When expressed in the yeast Saccharomyces cerevisiae, αSyn interacts with the plasma membrane, forms inclusions and causes a concentration-depe...

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Detalles Bibliográficos
Autores principales: De Graeve, Stijn, Marinelli, Sarah, Stolz, Frank, Hendrix, Jelle, Vandamme, Jurgen, Engelborghs, Yves, Van Dijck, Patrick, Thevelein, Johan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796869/
https://www.ncbi.nlm.nih.gov/pubmed/23924367
http://dx.doi.org/10.1042/BJ20130417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796869/
https://www.ncbi.nlm.nih.gov/pubmed/23924367
http://dx.doi.org/10.1042/BJ20130417

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