Insights from the computational analysis of CD271 glycation in mescenchymal stem cells in diabetes mellitus as a predisposition to latent tuberculosis

Diabetes mellitus is considered as a predisposition factor for active tuberculosis and is known to activate the latent form of tuberculosis. However, the causative association of latent tuberculosis with diabetes is not conclusively established. Therefore, it is of interest to relate their predispos...

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Autores principales: Bhattacharyya, Rajasri, Shukla, Misha, Nagra, Sachin, Banerjee, Dibyajyoti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2013
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796885/
https://www.ncbi.nlm.nih.gov/pubmed/24143054
http://dx.doi.org/10.6026/97320630009829
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author Bhattacharyya, Rajasri
Shukla, Misha
Nagra, Sachin
Banerjee, Dibyajyoti
author_facet Bhattacharyya, Rajasri
Shukla, Misha
Nagra, Sachin
Banerjee, Dibyajyoti
author_sort Bhattacharyya, Rajasri
collection PubMed
description Diabetes mellitus is considered as a predisposition factor for active tuberculosis and is known to activate the latent form of tuberculosis. However, the causative association of latent tuberculosis with diabetes is not conclusively established. Therefore, it is of interest to relate their predisposition. We describe the glycation pattern of mescenchymal stem cell surface markers as CD271+/CD45-mescenchymal stem cell is known to be associated with latent tuberculosis. We show that the lysine residues important for function of CD271 death domain are predicted to be and glycated. These observations help to discuss the role of CD271 and glycation to modulate the genesis of latent tuberculosis in chronic diabetic mellitus.
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spelling pubmed-37968852013-10-18 Insights from the computational analysis of CD271 glycation in mescenchymal stem cells in diabetes mellitus as a predisposition to latent tuberculosis Bhattacharyya, Rajasri Shukla, Misha Nagra, Sachin Banerjee, Dibyajyoti Bioinformation Hypothesis Diabetes mellitus is considered as a predisposition factor for active tuberculosis and is known to activate the latent form of tuberculosis. However, the causative association of latent tuberculosis with diabetes is not conclusively established. Therefore, it is of interest to relate their predisposition. We describe the glycation pattern of mescenchymal stem cell surface markers as CD271+/CD45-mescenchymal stem cell is known to be associated with latent tuberculosis. We show that the lysine residues important for function of CD271 death domain are predicted to be and glycated. These observations help to discuss the role of CD271 and glycation to modulate the genesis of latent tuberculosis in chronic diabetic mellitus. Biomedical Informatics 2013-09-23 /pmc/articles/PMC3796885/ /pubmed/24143054 http://dx.doi.org/10.6026/97320630009829 Text en © 2013 Biomedical Informatics This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Bhattacharyya, Rajasri
Shukla, Misha
Nagra, Sachin
Banerjee, Dibyajyoti
Insights from the computational analysis of CD271 glycation in mescenchymal stem cells in diabetes mellitus as a predisposition to latent tuberculosis
title Insights from the computational analysis of CD271 glycation in mescenchymal stem cells in diabetes mellitus as a predisposition to latent tuberculosis
title_full Insights from the computational analysis of CD271 glycation in mescenchymal stem cells in diabetes mellitus as a predisposition to latent tuberculosis
title_fullStr Insights from the computational analysis of CD271 glycation in mescenchymal stem cells in diabetes mellitus as a predisposition to latent tuberculosis
title_full_unstemmed Insights from the computational analysis of CD271 glycation in mescenchymal stem cells in diabetes mellitus as a predisposition to latent tuberculosis
title_short Insights from the computational analysis of CD271 glycation in mescenchymal stem cells in diabetes mellitus as a predisposition to latent tuberculosis
title_sort insights from the computational analysis of cd271 glycation in mescenchymal stem cells in diabetes mellitus as a predisposition to latent tuberculosis
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796885/
https://www.ncbi.nlm.nih.gov/pubmed/24143054
http://dx.doi.org/10.6026/97320630009829
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