A comprehensive analysis of LACK (Leishmania homologue of receptors for activated C kinase) in the context of Visceral Leishmaniasis

The Leishmania homologue of activated C kinase (LACK) a known T cell epitope from soluble Leishmania antigens (SLA) that confers protection against Leishmania challenge. This antigen has been found to be highly conserved among Leishmania strains. LACK has been shown to be protective against L. donov...

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Detalles Bibliográficos
Autores principales: Sinha, Sukrat, Kumar, Abhay, Sundaram, Shanthy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2013
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796886/
https://www.ncbi.nlm.nih.gov/pubmed/24143055
http://dx.doi.org/10.6026/97320630009832
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author Sinha, Sukrat
Kumar, Abhay
Sundaram, Shanthy
author_facet Sinha, Sukrat
Kumar, Abhay
Sundaram, Shanthy
author_sort Sinha, Sukrat
collection PubMed
description The Leishmania homologue of activated C kinase (LACK) a known T cell epitope from soluble Leishmania antigens (SLA) that confers protection against Leishmania challenge. This antigen has been found to be highly conserved among Leishmania strains. LACK has been shown to be protective against L. donovani challenge. A comprehensive analysis of several LACK sequences was completed. The analysis shows a high level of conservation, lower variability and higher antigenicity in specific portions of the LACK protein. This information provides insights for the potential consideration of LACK as a putative candidate in the context of visceral Leishmaniasis vaccine target.
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spelling pubmed-37968862013-10-18 A comprehensive analysis of LACK (Leishmania homologue of receptors for activated C kinase) in the context of Visceral Leishmaniasis Sinha, Sukrat Kumar, Abhay Sundaram, Shanthy Bioinformation Hypothesis The Leishmania homologue of activated C kinase (LACK) a known T cell epitope from soluble Leishmania antigens (SLA) that confers protection against Leishmania challenge. This antigen has been found to be highly conserved among Leishmania strains. LACK has been shown to be protective against L. donovani challenge. A comprehensive analysis of several LACK sequences was completed. The analysis shows a high level of conservation, lower variability and higher antigenicity in specific portions of the LACK protein. This information provides insights for the potential consideration of LACK as a putative candidate in the context of visceral Leishmaniasis vaccine target. Biomedical Informatics 2013-09-23 /pmc/articles/PMC3796886/ /pubmed/24143055 http://dx.doi.org/10.6026/97320630009832 Text en © 2013 Biomedical Informatics This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Sinha, Sukrat
Kumar, Abhay
Sundaram, Shanthy
A comprehensive analysis of LACK (Leishmania homologue of receptors for activated C kinase) in the context of Visceral Leishmaniasis
title A comprehensive analysis of LACK (Leishmania homologue of receptors for activated C kinase) in the context of Visceral Leishmaniasis
title_full A comprehensive analysis of LACK (Leishmania homologue of receptors for activated C kinase) in the context of Visceral Leishmaniasis
title_fullStr A comprehensive analysis of LACK (Leishmania homologue of receptors for activated C kinase) in the context of Visceral Leishmaniasis
title_full_unstemmed A comprehensive analysis of LACK (Leishmania homologue of receptors for activated C kinase) in the context of Visceral Leishmaniasis
title_short A comprehensive analysis of LACK (Leishmania homologue of receptors for activated C kinase) in the context of Visceral Leishmaniasis
title_sort comprehensive analysis of lack (leishmania homologue of receptors for activated c kinase) in the context of visceral leishmaniasis
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796886/
https://www.ncbi.nlm.nih.gov/pubmed/24143055
http://dx.doi.org/10.6026/97320630009832
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