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OTUD5 Regulates p53 Stability by Deubiquitinating p53

BACKGROUND: The p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell-cycle arrest genes in stressed cells. The stability of p53 is tightly regulated by ubiquitin-dependent degradation, driven mainly by its nega...

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Detalles Bibliográficos
Autores principales: Luo, Judong, Lu, Zhonghua, Lu, Xujing, Chen, Ling, Cao, Jianping, Zhang, Shuyu, Ling, Yang, Zhou, Xifa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797110/
https://www.ncbi.nlm.nih.gov/pubmed/24143256
http://dx.doi.org/10.1371/journal.pone.0077682
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author Luo, Judong
Lu, Zhonghua
Lu, Xujing
Chen, Ling
Cao, Jianping
Zhang, Shuyu
Ling, Yang
Zhou, Xifa
author_facet Luo, Judong
Lu, Zhonghua
Lu, Xujing
Chen, Ling
Cao, Jianping
Zhang, Shuyu
Ling, Yang
Zhou, Xifa
author_sort Luo, Judong
collection PubMed
description BACKGROUND: The p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell-cycle arrest genes in stressed cells. The stability of p53 is tightly regulated by ubiquitin-dependent degradation, driven mainly by its negative regulators ubiquitin ligase MDM2. PRINCIPAL FINDINGS: In this study, we have identified OTUD5 as a DUB that interacts with and deubiquitinates p53. OTUD5 forms a direct complex with p53 and controls level of ubiquitination. The function of OTUD5 is required to allow the rapid activation of p53-dependent transcription and a p53-dependent apoptosis in response to DNA damage stress. CONCLUSIONS: As a novel deubiquitinating enzyme for p53, OTUD5 is required for the stabilization and the activation of a p53 response.
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spelling pubmed-37971102013-10-18 OTUD5 Regulates p53 Stability by Deubiquitinating p53 Luo, Judong Lu, Zhonghua Lu, Xujing Chen, Ling Cao, Jianping Zhang, Shuyu Ling, Yang Zhou, Xifa PLoS One Research Article BACKGROUND: The p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell-cycle arrest genes in stressed cells. The stability of p53 is tightly regulated by ubiquitin-dependent degradation, driven mainly by its negative regulators ubiquitin ligase MDM2. PRINCIPAL FINDINGS: In this study, we have identified OTUD5 as a DUB that interacts with and deubiquitinates p53. OTUD5 forms a direct complex with p53 and controls level of ubiquitination. The function of OTUD5 is required to allow the rapid activation of p53-dependent transcription and a p53-dependent apoptosis in response to DNA damage stress. CONCLUSIONS: As a novel deubiquitinating enzyme for p53, OTUD5 is required for the stabilization and the activation of a p53 response. Public Library of Science 2013-10-15 /pmc/articles/PMC3797110/ /pubmed/24143256 http://dx.doi.org/10.1371/journal.pone.0077682 Text en © 2013 Luo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Luo, Judong
Lu, Zhonghua
Lu, Xujing
Chen, Ling
Cao, Jianping
Zhang, Shuyu
Ling, Yang
Zhou, Xifa
OTUD5 Regulates p53 Stability by Deubiquitinating p53
title OTUD5 Regulates p53 Stability by Deubiquitinating p53
title_full OTUD5 Regulates p53 Stability by Deubiquitinating p53
title_fullStr OTUD5 Regulates p53 Stability by Deubiquitinating p53
title_full_unstemmed OTUD5 Regulates p53 Stability by Deubiquitinating p53
title_short OTUD5 Regulates p53 Stability by Deubiquitinating p53
title_sort otud5 regulates p53 stability by deubiquitinating p53
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797110/
https://www.ncbi.nlm.nih.gov/pubmed/24143256
http://dx.doi.org/10.1371/journal.pone.0077682
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