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Identification of Mur34 as the Novel Negative Regulator Responsible for the Biosynthesis of Muraymycin in Streptomyces sp. NRRL30471

BACKGROUND: Muraymycin, a potent translocase I (MraY) inhibitor, is produced by Streptomyces sp. NRRL30471. The muraymycin gene cluster (mur) was recently cloned, and bioinformatic analysis of mur34 revealed its encoding product exhibits high homology to a large family of proteins, including KanI an...

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Detalles Bibliográficos
Autores principales: Xu, Dongmei, Liu, Guang, Cheng, Lin, Lu, Xinhua, Chen, Wenqing, Deng, Zixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797123/
https://www.ncbi.nlm.nih.gov/pubmed/24143177
http://dx.doi.org/10.1371/journal.pone.0076068