Pax6 Downregulation Mediates Abnormal Lineage Commitment of the Ocular Surface Epithelium in Aqueous-Deficient Dry Eye Disease

Keratinizing squamous metaplasia (SQM) of the ocular surface is a blinding consequence of systemic autoimmune disease and there is no cure. Ocular SQM is traditionally viewed as an adaptive tissue response during chronic keratoconjunctivitis sicca (KCS) that provokes pathological keratinization of t...

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Detalles Bibliográficos
Autores principales: Chen, Ying Ting, Chen, Feeling Y. T., Vijmasi, Trinka, Stephens, Denise N., Gallup, Marianne, McNamara, Nancy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797128/
https://www.ncbi.nlm.nih.gov/pubmed/24143217
http://dx.doi.org/10.1371/journal.pone.0077286

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