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Role of salvage radiotherapy for regional lymph node recurrence after radical surgery in advanced gastric cancer

PURPOSE: To evaluate the role of salvage radiotherapy (RT) for the treatment of regional lymph node recurrence (RLNR) after radical surgery in advanced gastric cancer. MATERIALS AND METHODS: We retrospectively analyzed medical records of 26 patients who underwent salvage treatment after diagnosis of...

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Autores principales: Kim, Byoung Hyuck, Eom, Keun-Yong, Kim, Jae-Sung, Kim, Hyung-Ho, Park, Do Joong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Radiation Oncology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797274/
https://www.ncbi.nlm.nih.gov/pubmed/24137560
http://dx.doi.org/10.3857/roj.2013.31.3.147
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author Kim, Byoung Hyuck
Eom, Keun-Yong
Kim, Jae-Sung
Kim, Hyung-Ho
Park, Do Joong
author_facet Kim, Byoung Hyuck
Eom, Keun-Yong
Kim, Jae-Sung
Kim, Hyung-Ho
Park, Do Joong
author_sort Kim, Byoung Hyuck
collection PubMed
description PURPOSE: To evaluate the role of salvage radiotherapy (RT) for the treatment of regional lymph node recurrence (RLNR) after radical surgery in advanced gastric cancer. MATERIALS AND METHODS: We retrospectively analyzed medical records of 26 patients who underwent salvage treatment after diagnosis of RLNR between 2006 and 2011. Patients with peritoneal seeding or distant metastasis were excluded. Eighteen patients received RT with or without chemotherapy and the other 8 did chemotherapy only without RT. A three-dimensional conformal RT was performed with median dose of 56 Gy (range, 44 to 60 Gy). Sixteen patients had fluoropyrimidine-based chemotherapy, 5 did taxane-based chemotherapy, and irinotecan was applied in 4. RESULTS: With a median follow-up of 20 months (range, 5 to 57 months), median overall survival (OS) and progression-free survival (PFS) after diagnosis of RLNR were 29 months and 12 months in the entire patients, respectively. Radiotherapy (p = 0.007) and disease-free interval (p = 0.033) were statistically significant factors for OS in multivariate analysis. Median OS was 36 months in patients who received RT and 16 months in those who did not. Furthermore, delivery of RT (p < 0.001), complete remission after salvage treatment (p = 0.040) and performance status (p = 0.023) were associated with a significantly better PFS. Gastrointestinal toxicities from RT were mild in most patients. CONCLUSION: Salvage RT combined with systemic chemotherapy may be an effective treatment managing RLNR from advanced gastric cancer.
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spelling pubmed-37972742013-10-17 Role of salvage radiotherapy for regional lymph node recurrence after radical surgery in advanced gastric cancer Kim, Byoung Hyuck Eom, Keun-Yong Kim, Jae-Sung Kim, Hyung-Ho Park, Do Joong Radiat Oncol J Original Article PURPOSE: To evaluate the role of salvage radiotherapy (RT) for the treatment of regional lymph node recurrence (RLNR) after radical surgery in advanced gastric cancer. MATERIALS AND METHODS: We retrospectively analyzed medical records of 26 patients who underwent salvage treatment after diagnosis of RLNR between 2006 and 2011. Patients with peritoneal seeding or distant metastasis were excluded. Eighteen patients received RT with or without chemotherapy and the other 8 did chemotherapy only without RT. A three-dimensional conformal RT was performed with median dose of 56 Gy (range, 44 to 60 Gy). Sixteen patients had fluoropyrimidine-based chemotherapy, 5 did taxane-based chemotherapy, and irinotecan was applied in 4. RESULTS: With a median follow-up of 20 months (range, 5 to 57 months), median overall survival (OS) and progression-free survival (PFS) after diagnosis of RLNR were 29 months and 12 months in the entire patients, respectively. Radiotherapy (p = 0.007) and disease-free interval (p = 0.033) were statistically significant factors for OS in multivariate analysis. Median OS was 36 months in patients who received RT and 16 months in those who did not. Furthermore, delivery of RT (p < 0.001), complete remission after salvage treatment (p = 0.040) and performance status (p = 0.023) were associated with a significantly better PFS. Gastrointestinal toxicities from RT were mild in most patients. CONCLUSION: Salvage RT combined with systemic chemotherapy may be an effective treatment managing RLNR from advanced gastric cancer. The Korean Society for Radiation Oncology 2013-09 2013-09-30 /pmc/articles/PMC3797274/ /pubmed/24137560 http://dx.doi.org/10.3857/roj.2013.31.3.147 Text en Copyright © 2013. The Korean Society for Radiation Oncology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Byoung Hyuck
Eom, Keun-Yong
Kim, Jae-Sung
Kim, Hyung-Ho
Park, Do Joong
Role of salvage radiotherapy for regional lymph node recurrence after radical surgery in advanced gastric cancer
title Role of salvage radiotherapy for regional lymph node recurrence after radical surgery in advanced gastric cancer
title_full Role of salvage radiotherapy for regional lymph node recurrence after radical surgery in advanced gastric cancer
title_fullStr Role of salvage radiotherapy for regional lymph node recurrence after radical surgery in advanced gastric cancer
title_full_unstemmed Role of salvage radiotherapy for regional lymph node recurrence after radical surgery in advanced gastric cancer
title_short Role of salvage radiotherapy for regional lymph node recurrence after radical surgery in advanced gastric cancer
title_sort role of salvage radiotherapy for regional lymph node recurrence after radical surgery in advanced gastric cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797274/
https://www.ncbi.nlm.nih.gov/pubmed/24137560
http://dx.doi.org/10.3857/roj.2013.31.3.147
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