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Triple pathology in patients with temporal lobe epilepsy: A case report and review of the literature
The coexistence of three intracranial lesions related to epileptic pathogenesis is known as ‘triple pathology’ and has rarely been reported. In this study we report a case of temporal lobe epilepsy (TLE) with the coexistence of hippocampal sclerosis (HS), focal cortical dysplasia (FCD) and gangliogl...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797311/ https://www.ncbi.nlm.nih.gov/pubmed/24137291 http://dx.doi.org/10.3892/etm.2013.1228 |
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author | YANG, KANG SU, JING HU, ZENGCHUN LANG, RUI SUN, XU LI, XINYU WANG, DONG WEI, MINGHAI YIN, JIAN |
author_facet | YANG, KANG SU, JING HU, ZENGCHUN LANG, RUI SUN, XU LI, XINYU WANG, DONG WEI, MINGHAI YIN, JIAN |
author_sort | YANG, KANG |
collection | PubMed |
description | The coexistence of three intracranial lesions related to epileptic pathogenesis is known as ‘triple pathology’ and has rarely been reported. In this study we report a case of temporal lobe epilepsy (TLE) with the coexistence of hippocampal sclerosis (HS), focal cortical dysplasia (FCD) and ganglioglioma in the temporal lobe. A 29-year-old male who had experienced recurrent seizures for four years was admitted to hospital. Cerebral magnetic resonance imaging (MRI) was conducted and T2-weighted and fluid-attenuated inversion recovery sequence (FLAIR) images revealed a reduced hippocampal volume with an increased FLAIR signal on the right side and a slightly enlarged temporal horn, which are typical imaging findings for HS and FCD. The patient underwent resectioning of the right anterior temporal lobe, hippocampus and amygdala, in addition to the lesion located in the medial temporal lobe. Immunohistochemical analysis of the medial temporal lobe lesion confirmed a ganglioglioma (WHO grade I) in the medial temporal lobe. During the first eight months following surgery, the patient's seizures were controlled with zonisamide and phenytoin. Electroencephalogram (EEG) assessment post-surgery confirmed the absence of epileptic discharges. Based on a literature review and a detailed review of this case, we postulate two possible explanations for the pathogenesis of ‘triple pathology’: i) ‘triple pathology’ is a combination of pathological progression and occasionality; and ii) ‘triple pathology’ lesions have similar pathological origins. |
format | Online Article Text |
id | pubmed-3797311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-37973112013-10-17 Triple pathology in patients with temporal lobe epilepsy: A case report and review of the literature YANG, KANG SU, JING HU, ZENGCHUN LANG, RUI SUN, XU LI, XINYU WANG, DONG WEI, MINGHAI YIN, JIAN Exp Ther Med Articles The coexistence of three intracranial lesions related to epileptic pathogenesis is known as ‘triple pathology’ and has rarely been reported. In this study we report a case of temporal lobe epilepsy (TLE) with the coexistence of hippocampal sclerosis (HS), focal cortical dysplasia (FCD) and ganglioglioma in the temporal lobe. A 29-year-old male who had experienced recurrent seizures for four years was admitted to hospital. Cerebral magnetic resonance imaging (MRI) was conducted and T2-weighted and fluid-attenuated inversion recovery sequence (FLAIR) images revealed a reduced hippocampal volume with an increased FLAIR signal on the right side and a slightly enlarged temporal horn, which are typical imaging findings for HS and FCD. The patient underwent resectioning of the right anterior temporal lobe, hippocampus and amygdala, in addition to the lesion located in the medial temporal lobe. Immunohistochemical analysis of the medial temporal lobe lesion confirmed a ganglioglioma (WHO grade I) in the medial temporal lobe. During the first eight months following surgery, the patient's seizures were controlled with zonisamide and phenytoin. Electroencephalogram (EEG) assessment post-surgery confirmed the absence of epileptic discharges. Based on a literature review and a detailed review of this case, we postulate two possible explanations for the pathogenesis of ‘triple pathology’: i) ‘triple pathology’ is a combination of pathological progression and occasionality; and ii) ‘triple pathology’ lesions have similar pathological origins. D.A. Spandidos 2013-10 2013-07-19 /pmc/articles/PMC3797311/ /pubmed/24137291 http://dx.doi.org/10.3892/etm.2013.1228 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles YANG, KANG SU, JING HU, ZENGCHUN LANG, RUI SUN, XU LI, XINYU WANG, DONG WEI, MINGHAI YIN, JIAN Triple pathology in patients with temporal lobe epilepsy: A case report and review of the literature |
title | Triple pathology in patients with temporal lobe epilepsy: A case report and review of the literature |
title_full | Triple pathology in patients with temporal lobe epilepsy: A case report and review of the literature |
title_fullStr | Triple pathology in patients with temporal lobe epilepsy: A case report and review of the literature |
title_full_unstemmed | Triple pathology in patients with temporal lobe epilepsy: A case report and review of the literature |
title_short | Triple pathology in patients with temporal lobe epilepsy: A case report and review of the literature |
title_sort | triple pathology in patients with temporal lobe epilepsy: a case report and review of the literature |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797311/ https://www.ncbi.nlm.nih.gov/pubmed/24137291 http://dx.doi.org/10.3892/etm.2013.1228 |
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