Structural basis for a class of nanomolar influenza A neuraminidase inhibitors

The influenza virus neuraminidase (NA) is essential for the virus life cycle. The rise of resistance mutations against current antiviral therapies has increased the need for the development of novel inhibitors. Recent efforts have targeted a cavity adjacent to the catalytic site (the 150-cavity) in...

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Detalles Bibliográficos
Autores principales: Kerry, Philip S., Mohan, Sankar, Russell, Rupert J. M., Bance, Nicole, Niikura, Masahiro, Pinto, B. Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797432/
https://www.ncbi.nlm.nih.gov/pubmed/24129600
http://dx.doi.org/10.1038/srep02871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797432/
https://www.ncbi.nlm.nih.gov/pubmed/24129600
http://dx.doi.org/10.1038/srep02871

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