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Targeting phosphodiesterase 3B enhances cisplatin sensitivity in human cancer cells

We previously reported that human squamous cell carcinoma (SCC) cell lines refractory to cis-diaminedichloro-platinum II (cisplatin [CDDP]) had significant upregulation of the phosphodiesterase 3B gene (PDE3B), suggesting that inhibiting PDE3B suppresses CDDP resistance. shRNA-mediated PDE3B depleti...

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Detalles Bibliográficos
Autores principales:	Uzawa, Katsuhiro, Kasamatsu, Atsushi, Baba, Takao, Usukura, Katsuya, Saito, Yasuhiro, Sakuma, Kentaro, Iyoda, Manabu, Sakamoto, Yosuke, Ogawara, Katsunori, Shiiba, Masashi, Tanzawa, Hideki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2013
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797561/ https://www.ncbi.nlm.nih.gov/pubmed/24133626 http://dx.doi.org/10.1002/cam4.56

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