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Targeting hedgehog signaling in cancer: research and clinical developments

Since its first description in Drosophila by Drs Nusslein-Volhard and Wieschaus in 1980, hedgehog (Hh) signaling has been implicated in regulation of cell differentiation, proliferation, tissue polarity, stem cell maintenance, and carcinogenesis. The first link of Hh signaling to cancer was establis...

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Detalles Bibliográficos
Autores principales: Xie, Jingwu, Bartels, Christopher M, Barton, Scott W, Gu, Dongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797650/
https://www.ncbi.nlm.nih.gov/pubmed/24143114
http://dx.doi.org/10.2147/OTT.S34678

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