Enhanced SCAP Glycosylation by Inflammation Induces Macrophage Foam Cell Formation

Inflammatory stress promotes foam cell formation by disrupting LDL receptor feedback regulation in macrophages. Sterol Regulatory Element Binding Proteins (SREBPs) Cleavage-Activating Protein (SCAP) glycosylation plays crucial roles in regulating LDL receptor and 3-hydroxy-3-methyl-glutaryl-CoA redu...

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Detalles Bibliográficos
Autores principales: Zhou, Chao, Lei, Han, Chen, Yaxi, Liu, Qing, Li, Lung-Chih, Moorhead, John F., Varghese, Zac, Ruan, Xiong Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797718/
https://www.ncbi.nlm.nih.gov/pubmed/24146768
http://dx.doi.org/10.1371/journal.pone.0075650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797718/
https://www.ncbi.nlm.nih.gov/pubmed/24146768
http://dx.doi.org/10.1371/journal.pone.0075650

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