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Enhanced SCAP Glycosylation by Inflammation Induces Macrophage Foam Cell Formation
Inflammatory stress promotes foam cell formation by disrupting LDL receptor feedback regulation in macrophages. Sterol Regulatory Element Binding Proteins (SREBPs) Cleavage-Activating Protein (SCAP) glycosylation plays crucial roles in regulating LDL receptor and 3-hydroxy-3-methyl-glutaryl-CoA redu...
Autores principales: | Zhou, Chao, Lei, Han, Chen, Yaxi, Liu, Qing, Li, Lung-Chih, Moorhead, John F., Varghese, Zac, Ruan, Xiong Z. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797718/ https://www.ncbi.nlm.nih.gov/pubmed/24146768 http://dx.doi.org/10.1371/journal.pone.0075650 |
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