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IL7Rα Expression and Upregulation by IFNβ in Dendritic Cell Subsets Is Haplotype-Dependent

The IL7Rα gene is unequivocally associated with susceptibility to multiple sclerosis (MS). Haplotype 2 (Hap 2) confers protection from MS, and T cells and dendritic cells (DCs) of Hap 2 exhibit reduced splicing of exon 6, resulting in production of relatively less soluble receptor, and potentially m...

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Detalles Bibliográficos
Autores principales:	McKay, Fiona C., Hoe, Edwin, Parnell, Grant, Gatt, Prudence, Schibeci, Stephen D., Stewart, Graeme J., Booth, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797747/ https://www.ncbi.nlm.nih.gov/pubmed/24147013 http://dx.doi.org/10.1371/journal.pone.0077508

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