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Stabilizing Exposure of Conserved Epitopes by Structure Guided Insertion of Disulfide Bond in HIV-1 Envelope Glycoprotein
Entry of HIV-1 into target cells requires binding of the viral envelope glycoprotein (Env) to cellular receptors and subsequent conformational changes that culminates in fusion of viral and target cell membranes. Recent structural information has revealed that these conformational transitions are re...
Autores principales: | Kassa, Aemro, Dey, Antu K., Sarkar, Pampi, Labranche, Celia, Go, Eden P., Clark, Daniel F., Sun, Yide, Nandi, Avishek, Hartog, Karin, Desaire, Heather, Montefiori, David, Carfi, Andrea, Srivastava, Indresh K., Barnett, Susan W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797752/ https://www.ncbi.nlm.nih.gov/pubmed/24146829 http://dx.doi.org/10.1371/journal.pone.0076139 |
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