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Estimated Glomerular Filtration Rate, All-Cause Mortality and Cardiovascular Diseases Incidence in a Low Risk Population: The MATISS Study

BACKGROUND: Chronic kidney disease (CKD) independently increases the risk of death and cardiovascular disease (CVD) in the general population. However, the relationship between estimated glomerular filtration rate (eGFR) and CVD/death risk in a general population at low risk of CVD has not been expl...

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Autores principales: Donfrancesco, Chiara, Palleschi, Simonetta, Palmieri, Luigi, Rossi, Barbara, Lo Noce, Cinzia, Pannozzo, Fabio, Spoto, Belinda, Tripepi, Giovanni, Zoccali, Carmine, Giampaoli, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797762/
https://www.ncbi.nlm.nih.gov/pubmed/24147135
http://dx.doi.org/10.1371/journal.pone.0078475
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author Donfrancesco, Chiara
Palleschi, Simonetta
Palmieri, Luigi
Rossi, Barbara
Lo Noce, Cinzia
Pannozzo, Fabio
Spoto, Belinda
Tripepi, Giovanni
Zoccali, Carmine
Giampaoli, Simona
author_facet Donfrancesco, Chiara
Palleschi, Simonetta
Palmieri, Luigi
Rossi, Barbara
Lo Noce, Cinzia
Pannozzo, Fabio
Spoto, Belinda
Tripepi, Giovanni
Zoccali, Carmine
Giampaoli, Simona
author_sort Donfrancesco, Chiara
collection PubMed
description BACKGROUND: Chronic kidney disease (CKD) independently increases the risk of death and cardiovascular disease (CVD) in the general population. However, the relationship between estimated glomerular filtration rate (eGFR) and CVD/death risk in a general population at low risk of CVD has not been explored so far. DESIGN: Baseline and longitudinal data of 1465 men and 1459 women aged 35-74 years participating to the MATISS study, an Italian general population cohort, were used to evaluate the role of eGFR in the prediction of all-cause mortality and incident CVD. METHODS: Bio-bank stored sera were used to evaluate eGFR at baseline. Serum creatinine was measured on thawed samples by means of an IDMS-calibrated enzymatic method. eGFR was calculated by the CKD-EPI formula. RESULTS: At baseline, less than 2% of enrolled persons had eGFR < 60 mL/min/1.73m(2) and more than 70% had a 10-year cardiovascular risk score < 10%. In people 60 or more years old, the first and the last eGFR quintiles (<90 and ≥109 mL/min/1.73m(2), respectively) were associated to an increased risk for both all-cause mortality (hazard ratio 1.6, 95% confidence interval 1.2-2.1 and 4.3, 1.6-11.7, respectively) and incident CVD (1.6, 1.0-2.4 and 7.0, 2.2-22.9, respectively), even if adjusted for classical risk factors. CONCLUSIONS: These findings strongly suggest that in an elderly, general population at low risk of CVD and low prevalence of reduced renal filtration, even a modest eGFR reduction is related to all-cause mortality and CVD incidence, underlying the potential benefit to this population of considering eGFR for their risk prediction.
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spelling pubmed-37977622013-10-21 Estimated Glomerular Filtration Rate, All-Cause Mortality and Cardiovascular Diseases Incidence in a Low Risk Population: The MATISS Study Donfrancesco, Chiara Palleschi, Simonetta Palmieri, Luigi Rossi, Barbara Lo Noce, Cinzia Pannozzo, Fabio Spoto, Belinda Tripepi, Giovanni Zoccali, Carmine Giampaoli, Simona PLoS One Research Article BACKGROUND: Chronic kidney disease (CKD) independently increases the risk of death and cardiovascular disease (CVD) in the general population. However, the relationship between estimated glomerular filtration rate (eGFR) and CVD/death risk in a general population at low risk of CVD has not been explored so far. DESIGN: Baseline and longitudinal data of 1465 men and 1459 women aged 35-74 years participating to the MATISS study, an Italian general population cohort, were used to evaluate the role of eGFR in the prediction of all-cause mortality and incident CVD. METHODS: Bio-bank stored sera were used to evaluate eGFR at baseline. Serum creatinine was measured on thawed samples by means of an IDMS-calibrated enzymatic method. eGFR was calculated by the CKD-EPI formula. RESULTS: At baseline, less than 2% of enrolled persons had eGFR < 60 mL/min/1.73m(2) and more than 70% had a 10-year cardiovascular risk score < 10%. In people 60 or more years old, the first and the last eGFR quintiles (<90 and ≥109 mL/min/1.73m(2), respectively) were associated to an increased risk for both all-cause mortality (hazard ratio 1.6, 95% confidence interval 1.2-2.1 and 4.3, 1.6-11.7, respectively) and incident CVD (1.6, 1.0-2.4 and 7.0, 2.2-22.9, respectively), even if adjusted for classical risk factors. CONCLUSIONS: These findings strongly suggest that in an elderly, general population at low risk of CVD and low prevalence of reduced renal filtration, even a modest eGFR reduction is related to all-cause mortality and CVD incidence, underlying the potential benefit to this population of considering eGFR for their risk prediction. Public Library of Science 2013-10-16 /pmc/articles/PMC3797762/ /pubmed/24147135 http://dx.doi.org/10.1371/journal.pone.0078475 Text en © 2013 Donfrancesco et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Donfrancesco, Chiara
Palleschi, Simonetta
Palmieri, Luigi
Rossi, Barbara
Lo Noce, Cinzia
Pannozzo, Fabio
Spoto, Belinda
Tripepi, Giovanni
Zoccali, Carmine
Giampaoli, Simona
Estimated Glomerular Filtration Rate, All-Cause Mortality and Cardiovascular Diseases Incidence in a Low Risk Population: The MATISS Study
title Estimated Glomerular Filtration Rate, All-Cause Mortality and Cardiovascular Diseases Incidence in a Low Risk Population: The MATISS Study
title_full Estimated Glomerular Filtration Rate, All-Cause Mortality and Cardiovascular Diseases Incidence in a Low Risk Population: The MATISS Study
title_fullStr Estimated Glomerular Filtration Rate, All-Cause Mortality and Cardiovascular Diseases Incidence in a Low Risk Population: The MATISS Study
title_full_unstemmed Estimated Glomerular Filtration Rate, All-Cause Mortality and Cardiovascular Diseases Incidence in a Low Risk Population: The MATISS Study
title_short Estimated Glomerular Filtration Rate, All-Cause Mortality and Cardiovascular Diseases Incidence in a Low Risk Population: The MATISS Study
title_sort estimated glomerular filtration rate, all-cause mortality and cardiovascular diseases incidence in a low risk population: the matiss study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797762/
https://www.ncbi.nlm.nih.gov/pubmed/24147135
http://dx.doi.org/10.1371/journal.pone.0078475
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